{{Rsnum
|rsid=73598374
|Gene=ADA
|Chromosome=20
|position=44651586
|Orientation=minus
|GMAF=0.04408
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ADA
}}{{PMID Auto
|PMID=20522203
|Title=Age- and gender-specific association between ADA (22G&gt;A) and TNF-alpha (-308G&gt;A) genetic polymorphisms
}}

{{omim
|id=102700
|rsnum=73598374
}}

{{omim
|id=608958
|rsnum=73598374
|variant=0021
}}

{{PMID Auto
|PMID=21865054
|Title=Age- and gender-specific epistasis between ADA and TNF-? influences human life-expectancy
}}

{{ClinVar
|rsid=73598374
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=43280227
|CHROM=20
|GMAF=0.044
|dbSNPBuildID=130
|SSR=0
|SAO=1
|VP=0x050368000000100016110100
|GENEINFO=ADA:100
|GENE_NAME=ADA
|GENE_ID=100
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000020.10:g.43280227C>T
|CLNORIGIN=0
|CLNSIG=5
|Tags=RV;PM;PMC;S3D;SLO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9559; 0.04408
|CLNACC=RCV000002050.1
|CLNDBN=Adenosine deaminase 2 allozyme
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=608958.0021
|COMMON=1
|Disease=Adenosine deaminase 2 allozyme
}}

{{PMID Auto
|PMID=21734253
|Title=Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans.
}}

{{GET Evidence
|gene=ADA
|aa_change=Asp8Asn
|aa_change_short=D8N
|impact=benign
|qualified_impact=Low clinical importance, Likely benign
|inheritance=dominant
|quality_scores=Array
|dbsnp_id=rs73598374
|overall_frequency_n=238
|overall_frequency_d=8058
|overall_frequency=0.0295359
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=7
|n_articles_annotated=7
|qualityscore_in_silico=0
|qualitycomment_in_silico=Y
|qualityscore_in_vitro=1
|qualitycomment_in_vitro=Y
|qualityscore_case_control=5
|qualitycomment_case_control=Y
|gene_in_genetests=Y
|in_omim=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-1
|autoscore=5
|webscore=N
|n_web_uneval=9
|variant_evidence=0
|clinical_importance=1
|summary_short=This common variant is reported to reduce adenosine deaminase enzyme activity. It has been associated with an increased tendency for non-REM sleep -- more slow wave sleep, less nocturnal wakings, and a stronger negative impact of sleep deprivation. A role for this gene and variant was previously proposed for autism susceptibility, but this is controversial and was not replicated by later studies.
}}

{{PMID Auto
|PMID=24896148
|Title=The functional polymorphism rs73598374:G&gt;A (p.Asp8Asn) of the ADA gene is associated with telomerase activity and leukocyte telomere length
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}