{{Rsnum
|rsid=737865
|Gene=COMT
|Chromosome=22
|position=19942598
|Orientation=minus
|GMAF=0.2392
|Gene_s=COMT,TXNRD2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 9.8 | 45.5 | 44.6
| HCB | 7.4 | 44.1 | 48.5
| JPT | 8.8 | 45.1 | 46.0
| YRI | 1.4 | 17.0 | 81.6
| ASW | 1.8 | 22.8 | 75.4
| CHB | 7.4 | 44.1 | 48.5
| CHD | 9.2 | 36.7 | 54.1
| GIH | 5.0 | 36.0 | 59.0
| LWK | 2.8 | 22.0 | 75.2
| MEX | 5.2 | 25.9 | 69.0
| MKK | 4.5 | 32.7 | 62.8
| TSI | 9.0 | 39.0 | 52.0
| HapMapRevision=28
}}part of a three marker haplotype [[rs737865]]-[[rs4680]]-[[rs165599]]

[[COMT]] haplotypes at [[rs737865]] and [[rs165599]] may predict a favorable outcome for [[bupropion]] treatment for [[smoking]] cessation.

We have typed the IVS 1 [[rs737865]] and 3' [[rs615599]] sites and also included a novel IVS 1 indel polymorphism. We report that the [[schizophrenia]]-associated haplotype is significantly heterogeneous in populations worldwide. {{PMID|15098000}}

may affect non-Hodgkin lymphoma, [[anxiety]]-related personality traits

Also mentioned in these PMIDs
*{{PMID|15124004}}
*{{PMID|15457404|OA=1
}}
*{{PMID|15505638}}
*{{PMID|15635644}}
*{{PMID|15956988}}
*{{PMID|16214922}}

{{PMID Auto
|PMID=19369177
|Title=Association of the 3' Region of COMT with Schizophrenia in Taiwan
}}

{{PMID Auto
|PMID=19290789
|Title=Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment
}}

{{PMID Auto
|PMID=19077118
|Title=Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia
}}

{{omim
|desc=ALZHEIMER DISEASE; AD
|id=104300
|rsnum=737865
}}

{{omim
|desc=CATECHOL-O-METHYLTRANSFERASE; COMT
|id=116790
|rsnum=737865
}}

{{PharmGKB
|RSID=rs737865
|Name_s=
|Gene_s=COMT, TXNRD2
|Feature=Intron, NA
|Evidence=PubMed ID:16876132
|Annotation=This variant may predict a favorable outcome for bupropion treatment for smoking cessation
|Drugs=bupropion
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162168064
}}

{{PharmGKB
|RSID=rs737865
|Name_s=
|Gene_s=COMT, TXNRD2
|Feature=Intron, NA
|Evidence=PubMed ID:18632656
|Annotation=This promoter variant is associated with breast cancer risk reduction in two of three case control studies. Functional studies showed that it altered nuclear protein binding patterns and was associated with the up-regulation of transcription, possibly resulting in increased COMT activity.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162168063
}}

{{PMID Auto
|PMID=21940152
|Title=The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study
}}

{{PMID Auto
|PMID=12802784
|Title=A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.
|OA=1
}}

{{PMID Auto
|PMID=15931594
|Title=An entropy-based statistic for genomewide association studies.
|OA=1
}}

{{PMID Auto
|PMID=16027741
|Title=Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.
}}

{{PMID Auto
|PMID=16232322
|Title=COMT genetic variation confers risk for psychotic and affective disorders: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=16483362
|Title=The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.
|OA=1
}}

{{PMID Auto
|PMID=16525418
|Title=Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.
}}

{{PMID Auto
|PMID=16816420
|Title=Nonlinear tests for genomewide association studies.
|OA=1
}}

{{PMID Auto
|PMID=16837108
|Title=Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.
}}

{{PMID Auto
|PMID=17363961
|Title=Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.
}}

{{PMID Auto
|PMID=17427186
|Title=Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.
}}

{{PMID Auto
|PMID=17466074
|Title=Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=17482701
|Title=No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.
}}

{{PMID Auto
|PMID=17630406
|Title=Dopamine genes and schizophrenia: case closed or evidence pending?
|OA=1
}}

{{PMID Auto
|PMID=17707347
|Title=Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.
|OA=1
}}

{{PMID Auto
|PMID=18081002
|Title=Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials.
}}

{{PMID Auto
|PMID=18384078
|Title=Association study of candidate variants of COMT with neuroticism, anxiety and depression.
}}

{{PMID Auto
|PMID=18436194
|Title=Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18574484
|Title=The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.
|OA=1
}}

{{PMID Auto
|PMID=18704099
|Title=Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18715757
|Title=Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=19071221
|Title=Impact of interacting functional variants in COMT on regional gray matter volume in human brain.
|OA=1
}}

{{PMID Auto
|PMID=19329282
|Title=Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.
}}

{{PMID Auto
|PMID=19365560
|Title=Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.
|OA=1
}}

{{PMID Auto
|PMID=19721400
|Title=Association between COMT gene and Chinese male schizophrenic patients with violent behavior.
}}

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{PMID Auto
|PMID=20531207
|Title=The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.
}}

{{PMID Auto
|PMID=20667552
|Title=Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21204206
|Title=Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population.
|OA=1
}}

{{PMID Auto
|PMID=21462137
|Title=[An association study of COMT gene polymorphisms with schizophrenia].
}}

{{PMID Auto
|PMID=21600957
|Title=COMT and age at onset in mood disorders: a replication and extension study.
}}

{{PMID Auto
|PMID=21656904
|Title=Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs737865
|overall_frequency_n=29
|overall_frequency_d=128
|overall_frequency=0.226562
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=2
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24382678
|Title=Association between maternal COMT gene polymorphisms and fetal neural tube defects risk in a Chinese population
}}

{{PMID Auto
|PMID=22705295
|Title=Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort.
}}

{{PMID Auto
|PMID=23178897
|Title=The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.
|OA=1
}}

{{PMID Auto
|PMID=23351565
|Title=Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability.
}}

{{PMID Auto
|PMID=23598060
|Title=Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}