{{Rsnum
|rsid=73885319
|Gene=APOL1
|Chromosome=22
|position=36265860
|Orientation=plus
|GMAF=0.04959
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=APOL1
}}The derived allele of coding SNP [[rs73885319]] (p.S342G) defines, together with the derived allele of coding SNP [[rs60910145]] (p.I384M), the APOL1 G1 allele. This allele has been shown to associate with kidney disease while conferring protection against Trypanosoma brucei rhodesiense. {{doi|10.1126/science.1193032}}

{{omim
|id=603743
|desc=APOLIPOPROTEIN L-I; APOL1
|rsnum=73885319
}}
{{omim
|id=603743
|rsnum=73885319
|variant=0001
}}{{PMID Auto
|PMID=20635188
|Title=Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.
|OA=1
}}{{GET Evidence
|gene=APOL1
|aa_change=Ser342Gly
|aa_change_short=S342G
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs73885319
|overall_frequency_n=821
|overall_frequency_d=10758
|overall_frequency=0.0763153
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=0
|n_articles_annotated=0
|nblosum100=2
|autoscore=0
|webscore=N
}}{{ClinVar
|ALT=G
|CAF=0.9504; 0.04959
|CHROM=22
|CLNALLE=1
|CLNHGVS=NC_000022.10:g.36661906A>G
|CLNSIG=255
|COMMON=1
|FwdALT=G
|FwdREF=A
|GENEINFO=APOL1:8542
|GENE_ID=8542
|GENE_NAME=APOL1
|REF=A
|RSPOS=36661906
|Reversed=0
|SAO=0
|SSR=1
|Tags=PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;LSD;OM
|VC=SNV
|VP=0x05016800000017051e110100
|WGT=0
|dbSNPBuildID=130
|rsid=73885319
|CLNACC=RCV000006453.1
|CLNDBN=Focal segmental glomerulosclerosis 4, susceptibility to
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C2675525:612551:656
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=603743.0001
|Disease=Focal segmental glomerulosclerosis 4
}}{{PMID Auto
|PMID=22956460
|Title=Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians.
|OA=1
}}