{{Rsnum
|rsid=742710
|Gene=CHGB
|Chromosome=20
|position=5923382
|Orientation=minus
|GMAF=0.1455
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CHGB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 6.2 | 93.8
| HCB | 2.9 | 31.6 | 65.4
| JPT | 0.9 | 16.8 | 82.3
| YRI | 7.5 | 38.8 | 53.7
| ASW | 7.0 | 26.3 | 66.7
| CHB | 2.9 | 31.6 | 65.4
| CHD | 4.6 | 28.7 | 66.7
| GIH | 2.0 | 25.7 | 72.3
| LWK | 8.3 | 42.2 | 49.5
| MEX | 6.9 | 34.5 | 58.6
| MKK | 3.2 | 30.1 | 66.7
| TSI | 0.0 | 9.8 | 90.2
| HapMapRevision=28
}}[http://blog.23andme.com/2009/12/09/snpwatch-a-new-genetic-variant-associated-with-als-risk-and-age-of-onset/ 23andMe blog] 2x risk of [[ALS]]

{{PMID|20007371|OA=1
}} Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis.

{{PMID|20932227}} The P413L chromogranin B variation in French patients with sporadic amyotrophic lateral sclerosis.

{{GET Evidence
|gene=CHGB
|aa_change=Pro413Leu
|aa_change_short=P413L
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs742710
|overall_frequency_n=1164
|overall_frequency_d=10758
|overall_frequency=0.108199
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|nblosum100=7
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}