{{Rsnum
|rsid=74315405
|Chromosome=20
|Orientation=plus
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene=PRNP
|position=4699813
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=PRNP
}}{{omim
|id=176640
|rsnum=74315405
|variant=0011
}}{{ClinVar
|rsid=74315405
|Reversed=0
|FwdREF=T
|FwdALT=C
|REF=T
|ALT=C
|RSPOS=4680459
|CHROM=20
|dbSNPBuildID=131
|SSR=0
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=PRNP:5621
|GENE_NAME=PRNP
|GENE_ID=5621
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000020.10:g.4680459T>C
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=NBK1229; 176640.0011
|CLNSIG=5
|CLNCUI=C0017495; C0162534
|CLNDBN=Gerstmann-Straussler-Scheinker syndrome; Genetic prion diseases
|Disease=Gerstmann-Straussler-Scheinker syndrome; Genetic prion diseases
|CLNACC=RCV000014340.23; RCV000020252.1
|Tags=PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:OMIM:Orphanet:SNOMED_CT; GeneReviews:MedGen
|CLNDSDBID=NBK1229:C0017495:137440:183000:356:67155006; NBK1229:C0162534
}}{{PMID Auto
|PMID=1357663
|Title=Prion protein preamyloid and amyloid deposits in Gerstmann-Straussler-Scheinker disease, Indiana kindred.
|OA=1
}}

{{PMID Auto
|PMID=1363809
|Title=Linkage of the Indiana kindred of Gerstmann-Straussler-Scheinker disease to the prion protein gene.
}}

{{PMID Auto
|PMID=1363810
|Title=Mutant prion proteins in Gerstmann-Straussler-Scheinker disease with neurofibrillary tangles.
}}

{{PMID Auto
|PMID=2812321
|Title=Gerstmann-Straussler-Scheinker disease. I. Extending the clinical spectrum.
}}

{{PMID Auto
|PMID=7954833
|Title=Amyloid fibrils in Gerstmann-Straussler-Scheinker disease (Indiana and Swedish kindreds) express only PrP peptides encoded by the mutant allele.
}}

{{PMID Auto
|PMID=12372829
|Title=Disease-associated F198S mutation increases the propensity of the recombinant prion protein for conformational conversion to scrapie-like form.
}}