{{Rsnum
|rsid=74315412
|Chromosome=20
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=PRNP
|position=4699843
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=PRNP
}}{{omim
|id=176640
|rsnum=74315412
|variant=0023
}}{{ClinVar
|rsid=74315412
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=4680489
|CHROM=20
|dbSNPBuildID=131
|SSR=0
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=PRNP:5621
|GENE_NAME=PRNP
|GENE_ID=5621
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000020.10:g.4680489G>A
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NBK1229; 176640.0023
|CLNSIG=5
|CLNCUI=C0022336; C0162534
|CLNDBN=Jakob-Creutzfeldt disease; Genetic prion diseases
|Disease=Jakob-Creutzfeldt disease; Genetic prion diseases
|CLNACC=RCV000014352.23; RCV000020254.1
|Tags=PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet:SNOMED_CT; GeneReviews:MedGen
|CLNDSDBID=NBK1229:C0022336:123400:204:792004; NBK1229:C0162534
}}{{PMID Auto
|PMID=8909447
|Title=Mutation of the prion protein gene at codon 208 in familial Creutzfeldt-Jakob disease.
}}

{{PMID Auto
|PMID=15753435
|Title=Creutzfeldt-Jakob disease associated with the R208H mutation in the prion protein gene.
}}

{{PMID Auto
|PMID=16533975
|Title=Familial Creutzfeldt-Jakob disease with an R208H-129V haplotype and Kuru plaques.
}}