{{Rsnum
|rsid=74315413
|Chromosome=20
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=PRNP
|position=4699780
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=PRNP
}}{{omim
|id=176640
|rsnum=74315413
|variant=0024
}}{{ClinVar
|rsid=74315413
|Reversed=0
|FwdREF=A
|FwdALT=G
|REF=A
|ALT=G
|RSPOS=4680426
|CHROM=20
|dbSNPBuildID=131
|SSR=0
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=PRNP:5621
|GENE_NAME=PRNP
|GENE_ID=5621
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000020.10:g.4680426A>G
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=NBK1229; 176640.0024
|CLNSIG=5
|CLNCUI=C0017495; C1847650; C0162534
|CLNDBN=Gerstmann-Straussler-Scheinker syndrome; Spongiform encephalopathy with neuropsychiatric features; Genetic prion diseases
|Disease=Gerstmann-Straussler-Scheinker syndrome; Spongiform encephalopathy with neuropsychiatric features; Genetic prion diseases
|CLNACC=RCV000014353.19; RCV000014354.23; RCV000020251.1
|Tags=PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:OMIM:Orphanet:SNOMED_CT; MedGen:OMIM; GeneReviews:MedGen
|CLNDSDBID=NBK1229:C0017495:137440:183000:356:67155006; C1847650:606688; NBK1229:C0162534
}}{{PMID Auto
|PMID=10581485
|Title=Novel PRNP sequence variant associated with familial encephalopathy.
}}

{{PMID Auto
|PMID=10953183
|Title=Inherited prion encephalopathy associated with the novel PRNP H187R mutation: a clinical study.
}}