{{Rsnum
|rsid=74315414
|Chromosome=20
|Orientation=plus
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene=PRNP
|position=4699533
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=PRNP
}}{{omim
|id=176640
|rsnum=74315414
|variant=0025
}}
{{omim
|id=176640
|rsnum=74315414
|variant=0027
}}{{ClinVar
|rsid=74315414
|Reversed=0
|FwdREF=C
|FwdALT=A,T
|REF=C
|ALT=A,T
|RSPOS=4680179
|CHROM=20
|dbSNPBuildID=131
|SSR=0
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=PRNP:5621
|GENE_NAME=PRNP
|GENE_ID=5621
|WGT=0
|VC=SNV
|CLNALLE=1; 2
|CLNHGVS=NC_000020.10:g.4680179C>A; NC_000020.10:g.4680179C>T
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NBK1229; 176640.0025; 176640.0027
|CLNSIG=5
|CLNCUI=C1847650; C0162534,C0017495; C0162534
|CLNDBN=Spongiform encephalopathy with neuropsychiatric features; Genetic prion diseases; Gerstmann-Straussler-Scheinker syndrome
|Disease=Spongiform encephalopathy with neuropsychiatric features; Genetic prion diseases; Gerstmann-Straussler-Scheinker syndrome
|CLNACC=RCV000014355.16; RCV000020240.1; RCV000014357.24; RCV000020241.1
|Tags=PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=MedGen:OMIM; GeneReviews:MedGen; GeneReviews:MedGen:OMIM:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=C1847650:606688; NBK1229:C0162534; NBK1229:C0017495:137440:183000:356:67155006
}}{{PMID Auto
|PMID=18955686
|Title=A novel PRNP-P105S mutation associated with atypical prion disease and a rare PrPSc conformation.
|OA=1
}}

{{PMID Auto
|PMID=16831973
|Title=Childhood onset in familial prion disease with a novel mutation in the PRNP gene.
}}