{{Rsnum
|rsid=743777
|Chromosome=22
|position=37155567
|Orientation=plus
|GMAF=0.2828
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 46.9 | 46.9 | 6.2
| HCB | 78.1 | 19.7 | 2.2
| JPT | 85.8 | 13.3 | 0.9
| YRI | 25.2 | 47.6 | 27.2
| ASW | 21.1 | 49.1 | 29.8
| CHB | 78.1 | 19.7 | 2.2
| CHD | 77.8 | 19.4 | 2.8
| GIH | 69.3 | 25.7 | 5.0
| LWK | 18.5 | 38.9 | 42.6
| MEX | 65.5 | 32.8 | 1.7
| MKK | 23.2 | 46.4 | 30.5
| TSI | 39.2 | 49.0 | 11.8
| HapMapRevision=28
}}[[rs743777]] has been reported in a large study to be associated with [[rheumatoid arthritis]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.09 (CI 0.97-1.24), and for homozygotes, 1.72 (CI 1.40-2.11). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs743777
|PubMedID=17554300
|Condition=Rheumatoid arthritis
|Gene=NR
|Risk Allele=G
|pValue=1.00E-006
|OR=1.09
|95CI=0.97-1.24
|OA=1
}}

{{PharmGKB
|RSID=rs743777
|Name_s=
|Gene_s=IL2RB
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,860 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs743777-G). This variant is associated with rheumatoid arthritis.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356657
}}

{{PMID Auto GWAS
|PMID=21653640
|Trait=None
|Title=Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.
|RiskAllele=G
|Pval=0.000002
|OR=1.1900
|ORtxt=[1.10-1.30]
}}

{{PMID Auto GWAS
|PMID=21829393
|Trait=None
|Title=Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|RiskAllele=G
|Pval=0.000002
|OR=1.1000
|ORtxt=[NR]
|OA=1
}}

{{PMID|18625055|OA=1
}} Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.

{{PMID|18794857|OA=1
}} Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

{{PMID|20017963|OA=1
}} Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.

{{PMID|20426808|OA=1
}} AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm.

{{PMID|20728947}} A novel galectin-1 and interleukin 2 receptor beta haplotype is associated with autoimmune myasthenia gravis.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs743777
|overall_frequency_n=43
|overall_frequency_d=128
|overall_frequency=0.335938
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22328738
|Title=Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}