{{Rsnum
|rsid=7439293
|Gene=PALLD
|Chromosome=4
|position=168756335
|Orientation=plus
|GMAF=0.3329
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PALLD
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 29.2 | 53.8 | 16.9
| HCB | 4.5 | 34.1 | 61.4
| JPT | 2.3 | 25.0 | 72.7
| YRI | 0.0 | 7.9 | 92.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 4.5 | 34.1 | 61.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs7439293]] is a SNP in the [[PALLD]] gene. The risk allele in terms of [[heart disease]] is [[rs7439293]](A).

This SNP is one of the 5 used by [[Celera]]'s genetic risk score (GRS) for coronary [[heart disease]] (CHD).

*[[rs20455]], in the [[KIF6]] gene
*[[rs3900940]], in the [[MYH15]] gene
*[[rs7439293]], in the [[PALLD]] gene
*[[rs2298566]], in the [[SNX19]] gene
*[[rs1010]], in the [[VAMP8]] gene

For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.{{PMID|18073581}}

{{ neighbor
| rsid = 12510359
| distance = 94
}}

{{PharmGKB
|RSID=rs7439293
|Name_s=
|Gene_s=PALLD
|Feature=
|Evidence=PubMed ID:18073581
|Annotation=This variant is associated with an elevated risk of coronary heart diseases.
|Drugs=
|Drug Classes=
|Diseases=Coronary Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA161795946
}}

{{PMID Auto
|PMID=18799872
|Title=Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study.
|OA=1
}}

{{PMID Auto
|PMID=19752551
|Title=Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry.
|OA=1
}}

{{PMID Auto
|PMID=21054356
|Title=Polymorphism of the palladin gene and cardiovascular outcome in patients with atherosclerosis.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7439293
|overall_frequency_n=44
|overall_frequency_d=128
|overall_frequency=0.34375
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=33
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}