{{Rsnum
|rsid=744154
|Gene=ERCC4
|Chromosome=16
|position=13921224
|Orientation=minus
|GMAF=0.214
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=ERCC4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 60.9 | 32.8 | 6.2
| HCB | 61.4 | 31.8 | 6.8
| JPT | 47.6 | 40.5 | 11.9
| YRI | 81.0 | 19.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 61.4 | 31.8 | 6.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

Previous studies had suggested that the minor allele of this SNP might influence breast cancer. However, a 2009 European study of 30,000 breast cancer cases, compared to 30,000 controls, found no association, or as they put it, "persuasive evidence against an overall association between invasive breast cancer risk and (this SNP)".{{PMID|19423537|OA=1
}}

{{PMID Auto
|PMID=19920816
|Title=Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)
|OA=1
}}

{{PMID Auto
|PMID=22573488
|Title=EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients
}}

{{PMID Auto
|PMID=22768293
|Title=Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis
|OA=1
}}
{{PMID Auto
|PMID=17018596
|Title=ERCC4 associated with breast cancer risk: a two-stage case-control study using high-throughput genotyping.
}}

{{PMID Auto
|PMID=17945097
|Title=[Influences of excision repair cross complementation group 4 genetic variations on DNA damage in lymphocytes among coke oven workers].
}}

{{PMID Auto
|PMID=20062074
|Title=A novel XPF -357A>C polymorphism predicts risk and recurrence of bladder cancer.
}}

{{PMID Auto
|PMID=23537993
|Title=Tagging SNPs in the ERCC4 gene are associated with gastric cancer risk
}}

{{PMID Auto
|PMID=23720401
|Title=Single Nucleotide Polymorphisms in Nucleotide Excision Repair Genes, Cigarette Smoking, and the Risk of Head and Neck Cancer
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}