{{Rsnum
|rsid=744166
|Gene=STAT3
|Chromosome=17
|position=42362183
|Orientation=minus
|GMAF=0.4541
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=STAT3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 24.8 | 40.7 | 34.5
| HCB | 13.1 | 45.3 | 41.6
| JPT | 15.9 | 49.6 | 34.5
| YRI | 54.1 | 39.0 | 6.8
| ASW | 45.6 | 36.8 | 17.5
| CHB | 13.1 | 45.3 | 41.6
| CHD | 14.8 | 52.8 | 32.4
| GIH | 26.7 | 43.6 | 29.7
| LWK | 48.2 | 40.0 | 11.8
| MEX | 5.2 | 43.1 | 51.7
| MKK | 59.4 | 32.3 | 8.4
| TSI | 16.7 | 47.1 | 36.3
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs744166
|PubMedID=18587394
|Condition=Crohn's disease
|Gene=STAT3
|Risk Allele=A
|pValue=7.00E-012
|OR=1.18
|95CI=
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 22; IBD22
|id=612380
|rsnum=744166
}}

{{PharmGKB
|RSID=rs744166
|Name_s=
|Gene_s=STAT3
|Feature=Intron
|Evidence=PubMed ID:18587394; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease (Initial Sample Size: 3,230 cases 4,829 controls; Replication Sample Size: 2,325 cases 1,809 controls 1,339 affected trios; Risk Allele: rs744166-A).
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356805
}}
{{PMID Auto
|PMID=19776189
|Title=Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults
}}

{{PMID Auto
|PMID=20109474
|Title=Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population
}}

{{PMID Auto
|PMID=20159113
|Title=Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene
|OA=1
}}

{{PMID Auto
|PMID=20222910
|Title=Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children
}}

{{omim
|id=126200
|rsnum=744166
}}

{{PMID Auto
|PMID=22205606
|Title=JAK2 and STAT3 polymorphisms in a Han Chinese Population with Behcet's disease
}}

{{PMID Auto
|PMID=22269120
|Title=Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease
}}

{{PMID Auto
|PMID=15657875
|Title=Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=18978678
|Title=Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
|OA=1
}}

{{PMID Auto
|PMID=19068216
|Title=Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
|OA=1
}}

{{PMID Auto
|PMID=19557189
|Title=Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
|OA=1
}}

{{PMID Auto
|PMID=19653082
|Title=Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=19915572
|Title=Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
|OA=1
}}

{{PMID Auto
|PMID=20179083
|Title=No association between myeloproliferative neoplasms and the Crohn's disease-associated STAT3 predisposition SNP rs744166.
}}

{{PMID Auto
|PMID=20200543
|Title=STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility.
}}

{{PMID Auto
|PMID=20405052
|Title=The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
|OA=1
}}

{{PMID Auto
|PMID=20454450
|Title=Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=22065112
|Title=The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.
}}

{{PMID Auto
|PMID=22095036
|Title=Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs744166
|overall_frequency_n=67
|overall_frequency_d=128
|overall_frequency=0.523438
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=62
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23127549
|Title=Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease
}}

{{PMID Auto
|PMID=23611997
|Title=JAK1, but not JAK2 and STAT3, confers susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population
}}

{{PMID Auto
|PMID=24081513
|Title=Association of single-nucleotide polymorphisms in the STAT3 gene with autoimmune thyroid disease in Chinese individuals
|OA=1
}}

{{PMID Auto
|PMID=24864251
|Title=rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population
}}

{{PMID Auto
|PMID=25132422
|Title=An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}