{{Rsnum
|rsid=7442295
|Gene=SLC2A9
|Chromosome=4
|position=9964756
|Orientation=plus
|GMAF=0.2172
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SLC2A9
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 60.2 | 37.2 | 2.7
| HCB | 99.3 | 0.7 | 0.0
| JPT | 98.2 | 1.8 | 0.0
| YRI | 31.5 | 52.1 | 16.4
| ASW | 31.6 | 54.4 | 14.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 91.5 | 8.5 | 0.0
| GIH | 66.3 | 28.7 | 5.0
| LWK | 35.8 | 49.5 | 14.7
| MEX | 44.8 | 43.1 | 12.1
| MKK | 48.7 | 45.3 | 6.0
| TSI | 61.8 | 34.3 | 3.9
| HapMapRevision=28
}}
[[rs7442295]] is a SNP in the [[SLC2A9]] gene; this gene encodes a glucose transporter.

Based on an initial study of 1900+ hypertensive Caucasian Europeans, the more common allele [[rs7442295]](A) allele was associated with higher serum urate and hyperuracemia (defined as urate >0.4 mMol/l), with a reported odds ratio of 1.89 (CI: 1.36-2.61, p=5 x 10<sup>-5</sup>). This was also seen in an associated meta-analysis conducted with a broadly representative population and using a surrogate SNP, [[rs6449213]], which is in fairly tight linkage (r<sup>2</sup>=0.88) with [[rs7442295]].{{PMID|18179892|OA=1
}}

To put it another way, 79% of white Europeans carry one or two alleles leading to higher serum urate levels. Each copy leads to an average increase of 0.02mMol/l, and, an ~doubling of risk for hyperuracemia.{{PMID|18179892|OA=1
}}

{{GWAS Summary
|SNP=rs7442295
|PubMedID=18179892
|Condition=Serum urate
|Gene=SLC2A9,WDR1
|Risk Allele=A
|pValue=2.00E-015
|OR=0.02
|95CI=0.02-0.03) mMol/L highe
|OA=1
}}

{{PMID Auto GWAS
|PMID=18327256
|Trait=Serum urate
|Title=SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
|RiskAllele=C
|Pval=3.0000000000000001E-70
|OR=0.35
|ORtxt=[NR] mg/dl decrease in uric acid
}}

{{omim
|desc=HYPOURICEMIA, RENAL, 2; RHUC2
|id=612076
|rsnum=7442295
}}

{{omim
|id=606142
|desc=SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER
|rsnum=7442295
}}

{{PharmGKB
|RSID=rs7442295
|Name_s=
|Gene_s=SLC2A9
|Feature=
|Evidence=PubMed ID:18179892; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia (Initial Sample Size: 1,955 hypertensive individuals; Replication Sample Size: 2,033 individuals in 519 families; 1,461 twins (1/pair selected randomly); Risk Allele: rs7442295-A). This variant is associated with serum urate levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356704
}}

{{PharmGKB
|RSID=rs7442295
|Name_s=
|Gene_s=SLC2A9
|Feature=
|Evidence=PubMed ID:18327256; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: SLC2A9 influences uric acid concentrations with pronounced sex-specific effects (Initial Sample Size: 1,644 individuals; Replication Sample Size: 9,947 individuals; Risk Allele: rs7442295-C).
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356758
}}

{{omim
|id=606142
|rsnum=7442295
|variant=0001
}}

{{PMID Auto
|PMID=17997608
|Title=The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.
|OA=1
}}

{{PMID Auto
|PMID=18398472
|Title=Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study.
|OA=1
}}

{{PMID Auto
|PMID=18487473
|Title=Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI.
|OA=1
}}

{{PMID Auto
|PMID=18606621
|Title=SLC2A9--a fructose transporter identified as a novel uric acid transporter.
|OA=1
}}

{{PMID Auto
|PMID=19679263
|Title=Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.
|OA=1
}}

{{PMID Auto
|PMID=20053405
|Title=Sex and age interaction with genetic association of atherogenic uric acid concentrations.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7442295
|overall_frequency_n=32
|overall_frequency_d=128
|overall_frequency=0.25
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=33
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23422251
|Title=Short communication: genetic variations of SLC2A9 in relation to Parkinson's disease
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}