{{Rsnum
|rsid=7454108
|Chromosome=6
|position=32713706
|Orientation=plus
|GMAF=0.09826
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=Higher risk of type-1 diabetes
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 3.5 | 29.2 | 67.3
| HCB | 0.0 | 11.7 | 88.3
| JPT | 1.8 | 18.6 | 79.6
| YRI | 0.0 | 4.8 | 95.2
| ASW | 0.0 | 14.0 | 86.0
| CHB | 0.0 | 11.7 | 88.3
| CHD | 0.0 | 11.9 | 88.1
| GIH | 3.0 | 12.9 | 84.2
| LWK | 0.0 | 4.5 | 95.5
| MEX | 1.7 | 37.9 | 60.3
| MKK | 0.6 | 14.7 | 84.6
| TSI | 0.0 | 7.9 | 92.1
| HapMapRevision=28
}}{{PMID|18694972|OA=1
}} People with the human leukocyte antigen (HLA) genotype DRB1*0301-DQA1*0501-DQB1*0201/DRB1*04-DQA1*0301-DQB1*0302 (more simply known as "DR3/4-DQ8") are at the highest risk of developing [[type-1 diabetes]].

The [[rs2040410]](A) allele is associated with DRB1*0301, and the [[rs7454108]](C) allele is associated with DQB1*0302 (and thus DQ8).

Instead of more traditional antibody-based tests, two SNPs ([[rs2040410]] and [[rs7454108]]) can be used to identify the presence or absence of the DR3/4-DQ8 genotype and thus the highest-risk heterozygous genotype associated with [[type-1 diabetes]]. For users of [[Promethease]], this is determined via [[Gs121]].

{{ neighbor
| rsid = 2858331
| distance = 206
}}

{{PMID Auto
|PMID=15747258
|Title=A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=18509540
|Title=Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19143815
|Title=MHC fine mapping of human type 1 diabetes using the T1DGC data.
|OA=1
}}

{{PMID Auto
|PMID=19143817
|Title=Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex.
|OA=1
}}

{{PMID Auto
|PMID=19455305
|Title=No association of multiple type 2 diabetes loci with type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=22511809
|Title=Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}