{{Rsnum
|rsid=7483
|Gene=GSTM3
|Chromosome=1
|position=109737079
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3806
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=GSTM3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 8.8 | 44.2 | 46.9
| HCB | 53.3 | 39.4 | 7.3
| JPT | 53.6 | 39.3 | 7.1
| YRI | 0.0 | 5.4 | 94.6
| ASW | 1.8 | 17.5 | 80.7
| CHB | 53.3 | 39.4 | 7.3
| CHD | 54.1 | 38.5 | 7.3
| GIH | 16.8 | 51.5 | 31.7
| LWK | 1.8 | 20.2 | 78.0
| MEX | 19.0 | 43.1 | 37.9
| MKK | 1.3 | 23.1 | 75.6
| TSI | 6.9 | 43.1 | 50.0
| HapMapRevision=28
}}

{{PMID|18423940}} association of the rs7483 SNP with late-onset [[Alzheimer's disease]]

{{PMID Auto
|PMID=19696791
|Title=Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori
}}

{{PMID Auto
|PMID=16112301
|Title=NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.
|OA=1
}}

{{PMID Auto
|PMID=17601350
|Title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
|OA=1
}}

{{PMID Auto
|PMID=17904251
|Title=Gene variations in GSTM3 are a risk factor for Alzheimer's disease.
}}

{{PMID Auto
|PMID=19151192
|Title=Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function.
|OA=1
}}

{{PMID Auto
|PMID=19223546
|Title=Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=21799460
|Title=HapMap-based study of human soluble glutathione S-transferase enzymes: the role of natural selection in shaping the single nucleotide polymorphism diversity of xenobiotic-metabolizing genes.
}}

{{PMID Auto
|PMID=23036584
|Title=Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease
}}

{{GET Evidence
|gene=GSTM3
|aa_change=Val224Ile
|aa_change_short=V224I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7483
|overall_frequency_n=2498
|overall_frequency_d=10758
|overall_frequency=0.232199
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=0
|n_articles_annotated=0
|nblosum100=-4
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24157827
|Title=Genetic variation in the GSTM3 promoter confer risk and prognosis of renal cell carcinoma by reducing gene expression
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}