{{Rsnum
|rsid=748693
|Gene=KCNH2
|Chromosome=7
|position=150974349
|Orientation=plus
|GMAF=0.2401
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=KCNH2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 46.0 | 39.8 | 14.2
| HCB | 65.7 | 31.4 | 2.9
| JPT | 74.3 | 23.9 | 1.8
| YRI | 85.0 | 15.0 | 0.0
| ASW | 68.4 | 28.1 | 3.5
| CHB | 65.7 | 31.4 | 2.9
| CHD | 72.5 | 23.9 | 3.7
| GIH | 39.0 | 41.0 | 20.0
| LWK | 76.4 | 23.6 | 0.0
| MEX | 51.7 | 36.2 | 12.1
| MKK | 73.1 | 24.4 | 2.6
| TSI | 48.0 | 45.1 | 6.9
| HapMapRevision=28
}}[http://genes2brains2mentalhealth.wordpress.com/2009/08/22/timing-is-everything-k-channel-bears-the-evidence-across-milliseconds-and-millenia/ g2b2mh] [[rs3800779]] [[rs748693]] and [[rs1036145]] are associated with a variety of brain parameters such as hippocampal volume, hippocampal activity (declarative memory task) and activity in the dorsolateral prefrontal cortex (DLPFC). The main suggestion of how these variants in KCNH2 might lead to these brain changes and risk for [[schizophrenia]] comes from previous findings that mutations in this gene screw up the efflux of K+ ions during the repolarization phase of an action potential.

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}