{{Rsnum
|rsid=7493
|Gene=PON2
|Chromosome=7
|position=95405463
|Orientation=minus
|GMAF=0.2567
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=PON2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 62.8 | 34.5 | 2.7
| HCB | 67.9 | 30.7 | 1.5
| JPT | 69.0 | 27.4 | 3.5
| YRI | 42.9 | 44.9 | 12.2
| ASW | 57.9 | 28.1 | 14.0
| CHB | 67.9 | 30.7 | 1.5
| CHD | 66.1 | 29.4 | 4.6
| GIH | 37.6 | 45.5 | 16.8
| LWK | 36.4 | 50.9 | 12.7
| MEX | 55.2 | 37.9 | 6.9
| MKK | 55.8 | 36.5 | 7.7
| TSI | 58.8 | 38.2 | 2.9
| HapMapRevision=28
}}[[rs7493]], also known as Ser311Cys, is a missense SNP in the paraoxonase 2 ([[PON2]]) gene.

A study has shown that inheriting the Cys version encoded by the corresponding SNP results in impaired (lower) lactonase activity; this may (or may not) lead to problems with innate immunity, atherosclerosis, and other diseases.{{PMID|19840942|OA=1
}}

{{omim
|id=602447
|rsnum=7493
|variant=0001
}}

{{PMID Auto
|PMID=22016051
|Title=Leads from xenobiotic metabolism genes for Parkinson's disease among north Indians
}}

{{ClinVar
|rsid=7493
|Reversed=1
|FwdREF=C
|FwdALT=G
|REF=G
|ALT=C
|RSPOS=95034775
|CHROM=7
|GMAF=0.2569
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05037800000017051f110101
|GENEINFO=PON2:5445
|GENE_NAME=PON2
|GENE_ID=5445
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000007.13:g.95034775G>C
|CLNORIGIN=1
|CLNSIG=2
|Tags=RV;PM;TPA;PMC;S3D;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7433; 0.2567
|CLNACC=RCV000007500.1
|CLNDBN=PARAOXONASE 2 POLYMORPHISM
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=602447.0001
|COMMON=1
|Disease=PARAOXONASE 2 POLYMORPHISM
}}

{{PMID Auto
|PMID=17601350
|Title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
|OA=1
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=19104460
|Title=Interaction between PON1 and population density in amyotrophic lateral sclerosis.
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19321847
|Title=A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.
|OA=1
}}

{{PMID Auto
|PMID=19379518
|Title=Development of a fingerprinting panel using medically relevant polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19546579
|Title=Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans.
|OA=1
}}

{{PMID Auto
|PMID=19587357
|Title=A systematic meta-analysis of genetic association studies for diabetic retinopathy.
|OA=1
}}

{{PMID Auto
|PMID=20056567
|Title=Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.
|OA=1
}}

{{PMID Auto
|PMID=20381198
|Title=Lack of association of PON polymorphisms with sporadic ALS in an Italian population.
}}

{{PMID Auto
|PMID=20565774
|Title=Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
|OA=1
}}

{{PMID Auto
|PMID=21223581
|Title=Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=21231776
|Title=C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging.
}}

{{GET Evidence
|gene=PON2
|aa_change=Ser311Cys
|aa_change_short=S311C
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7493
|overall_frequency_n=2651
|overall_frequency_d=10758
|overall_frequency=0.246421
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=33
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22877234
|Title=Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Meniere's disease in a Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=22884547
|Title=Association analysis of PON polymorphisms in sporadic ALS in a Chinese population.
}}

{{PMID Auto
|PMID=23327886
|Title=Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population.
}}

{{PMID Auto
|PMID=24100645
|Title=Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}