{{Rsnum
|rsid=7495174
|Gene=OCA2
|Chromosome=15
|position=28099092
|Orientation=plus
|GMAF=0.2585
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=OCA2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 90.3 | 9.7 | 0.0
| HCB | 14.7 | 43.4 | 41.9
| JPT | 14.2 | 39.8 | 46.0
| YRI | 71.2 | 26.0 | 2.7
| ASW | 71.9 | 26.3 | 1.8
| CHB | 14.7 | 43.4 | 41.9
| CHD | 9.3 | 44.9 | 45.8
| GIH | 49.5 | 43.6 | 6.9
| LWK | 60.9 | 34.5 | 4.5
| MEX | 65.5 | 32.8 | 1.7
| MKK | 69.2 | 26.3 | 4.5
| TSI | 70.6 | 25.5 | 3.9
| HapMapRevision=28
}}[[rs7495174]] is located in intron 1 of the [[OCA2]] gene. The (A) allele (in dbSNP orientation) is associated with blue or green [[eye color]] in Caucasians. {{PMID|17236130|OA=1
}}.

This SNP is 1 of 3 SNPs defining a haplotype that has been studied for association with [[eye color]]. The full details on the correspondence between the haplotype and [[eye color]] can be found on the [[OCA2]] page.

{{omim
|desc=SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 1; SHEP1
|id=227220
|rsnum=7495174
}}

{{omim
|id=611409
|desc=OCA2 GENE
|rsnum=7495174
}}

{{PharmGKB
|RSID=rs7495174
|Name_s=
|Gene_s=OCA2
|Feature=
|Evidence=PubMed ID:17236130
|Annotation=A haplotype containing rs11855019, rs6497268 and rs7495174 was highly associated with eye color, hair color and skin pigmentation in a mostly Northern European twin study.
|Drugs=
|Drug Classes=
|Diseases=Melanoma; Skin Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162167954
}}

{{omim
|id=611409
|rsnum=7495174
|variant=0013
}}

{{PMID Auto
|PMID=18252221
|Title=Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.
|OA=1
}}

{{PMID Auto
|PMID=18252222
|Title=A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color.
|OA=1
}}

{{PMID Auto
|PMID=18483556
|Title=A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
|OA=1
}}

{{PMID Auto
|PMID=18683857
|Title=Variants of the MATP/SLC45A2 gene are protective for melanoma in the French population.
}}

{{PMID Auto
|PMID=19340012
|Title=Genome-wide association study of tanning phenotype in a population of European ancestry.
|OA=1
}}

{{PMID Auto
|PMID=19472299
|Title=Genotyping of five single nucleotide polymorphisms in the OCA2 and HERC2 genes associated with blue-brown eye color in the Japanese population.
}}

{{PMID Auto
|PMID=20042077
|Title=Genetic determinants of hair and eye colours in the Scottish and Danish populations.
|OA=1
}}

{{PMID Auto
|PMID=20221248
|Title=Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7495174
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23100201
|Title=A single-nucleotide polymorphism (SNP) multiplex system: the association of five SNPs with human eye and hair color in the Slovenian population and comparison using a Bayesian network and logistic regression model
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}