{{Rsnum
|rsid=7501331
|Gene=BCMO1
|Chromosome=16
|position=81280891
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.1621
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=BCMO1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 45.9 | 49.5 | 4.5
| HCB | 67.9 | 31.4 | 0.7
| JPT | 71.8 | 27.3 | 0.9
| YRI | 100.0 | 0.0 | 0.0
| ASW | 89.5 | 10.5 | 0.0
| CHB | 67.9 | 31.4 | 0.7
| CHD | 72.2 | 26.9 | 0.9
| GIH | 58.6 | 33.3 | 8.1
| LWK | 0.0 | 0.0 | 0.0
| MEX | 75.4 | 21.1 | 3.5
| MKK | 96.8 | 3.2 | 0.0
| TSI | 72.5 | 23.5 | 3.9
| HapMapRevision=28
}}

{{PMID|19103647}} [[rs12934922]] (R267S) and [[rs7501331]] (A379V) double mutant have a reduced catalytic activity of beta-carotene by 57%.  Female volunteers carrying the T variant of [[rs7501331]] (379V) had a 32% lower ability to convert Beta-carotene, and those carrying at least one T in both SNPs show a 69% lower ability to convert Beta-carotene into retinyl esters.

[[rs7501331]]: the frequency of the wild-type C allele and variant T allele was 76 and 24%, respectively; 56% of the population was CC wild-type genotype, and 39% was heterozygote CT with the TT variant present in 5% of the population.

[[rs12934922]]: the frequency of the wild-type A allele and variant T allele was 58 and 42%, respectively; 38% of the population was AA wild-type genotype, 40% was heterozygote AT, and 22% was TT homozygote

{{PMID Auto
|PMID=19557453
|Title=beta-Carotene conversion products and their effects on adipose tissue.
|OA=1
}}

{{PMID Auto
|PMID=19844255
|Title=Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.
|OA=1
}}

{{PMID Auto
|PMID=21091228
|Title=Genetic variants in BCMO1 and CD36 are associated with plasma lutein concentrations and macular pigment optical density in humans.
}}

{{PMID Auto
|PMID=22113863
|Title=Single nucleotide polymorphisms upstream from the beta-carotene 15,15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteers.
}}

{{GET Evidence
|gene=BCMO1
|aa_change=Ala379Val
|aa_change_short=A379V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7501331
|overall_frequency_n=1820
|overall_frequency_d=10758
|overall_frequency=0.169176
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=12
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.011
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}