{{Rsnum
|rsid=7501939
|Gene=HNF1B
|Chromosome=17
|position=37741165
|Orientation=plus
|GMAF=0.3861
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HNF1B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 28.3 | 56.6 | 15.0
| HCB | 58.4 | 35.8 | 5.8
| JPT | 44.2 | 46.9 | 8.8
| YRI | 14.3 | 53.1 | 32.7
| ASW | 23.2 | 53.6 | 23.2
| CHB | 58.4 | 35.8 | 5.8
| CHD | 62.4 | 29.4 | 8.3
| GIH | 50.5 | 41.6 | 7.9
| LWK | 16.4 | 47.3 | 36.4
| MEX | 46.6 | 48.3 | 5.2
| MKK | 13.5 | 44.2 | 42.3
| TSI | 35.6 | 44.6 | 19.8
| HapMapRevision=28
}}

[http://www.cancerpage.com/news/article.asp?id=11059] related to [[Prostate cancer]] and [[Type-2 diabetes]]

{{PMID|18701471|OA=1
}} The increased risk associated with [[rs7501939]] and the closely linked [[rs4430796]] is approximately doubled in individuals hereditarily predisposed to develop early-onset [[prostate cancer]], based on a study of ~1,000 men.

{{PMID|19998368|OA=1
}} [[rs7501939]] identified as one of three [[HNF1B]] gene SNPs associated with decreased risk for [[prostate cancer]] in two large prospective studies 

[http://cancergenetics.wordpress.com/2008/02/15/prostate-cancer-oldnew-snps-and-decodeprca/ cancer-genetics] these SNPs influence genetic risk for [[prostate cancer]]
*the [[haplotype]] [[rs6983267]] [[rs1016343]] [[rs4242384]] 
*[[rs7501939]] 
*[[rs1859962]]
*[[rs2660753]]
*[[rs9364554]]
*[[rs6465657]]
*[[rs10993994]]
*[[rs7931342]]
*[[rs2735839]]
*[[rs5945619]]
*[[rs10993994]]

{{PMID Auto GWAS
|PMID=18264097
|Trait=Prostate cancer
|Title=Multiple newly identified loci associated with prostate cancer susceptibility
|RiskAllele=C
|Pval=8.9999999999999996E-12
|OR=1.41
|ORtxt=[NR]
}}

{{omim
|desc=PROSTATE CANCER, HEREDITARY, 11; HPC11
|id=611955
|rsnum=7501939
}}
{{PMID Auto GWAS
|PMID=19767753
|Trait=Prostate cancer
|Title=Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
|RiskAllele=C
|Pval=3E-18
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PMID Auto GWAS
|PMID=20676098
|Trait=None
|Title=Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
|RiskAllele=
|Pval=1E-12
|OR=None
|ORtxt=None
}}

{{PMID Auto GWAS
|PMID=21743057
|Trait=None
|Title=Genome-wide association study identifies new prostate cancer susceptibility loci.
|RiskAllele=C
|Pval=0.000002
|OR=1.1900
|ORtxt=[1.11-1.28]
|OA=1
}}

{{PMID Auto
|PMID=22299039
|Title=HNF1B and Endometrial Cancer Risk: Results from the PAGE study
|OA=1
}}

{{PMID Auto
|PMID=18426861
|Title=Association analysis of type 2 diabetes Loci in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18974127
|Title=Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=19096518
|Title=Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19168595
|Title=Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=19401414
|Title=Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=19455305
|Title=No association of multiple type 2 diabetes loci with type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=20509872
|Title=Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=20690139
|Title=Meta-analysis of genome-wide and replication association studies on prostate cancer.
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7501939
|overall_frequency_n=73
|overall_frequency_d=120
|overall_frequency=0.608333
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24422606
|Title=Assessment of Association between Common Variants at 17q12 and Prostate Cancer Risk-Evidence from Serbian Population and Meta-Analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}