{{Rsnum
|rsid=750332
|Gene=BAT3
|Chromosome=6
|position=31639273
|Orientation=minus
|GMAF=0.1593
|Gene_s=BAG6
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{PharmGKB
|RSID=rs750332
|Name_s=
|Gene_s=BAT2, BAT3
|Feature=
|Evidence=PubMed ID:16538176
|Annotation=Risk or phenotype-associated allele: C allele. Phenotype: The C allele of rs750332 shows strong association with carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS)/Toxic Epidermal Necrolysis (TEN, Lyell's syndrome). Study size: 204. Study population/ethnicity: 60 CBZ-induced SJS/TEN cases and 144 CBZ-tolerant controls of Chinese descent. Significance metric(s): p = 3.04x10(-14), Pc = 8.45x10(-12), OR = 6.41. Type of association: GN; PD; TOX; ADR.
|Drugs=carbamazepine
|Drug Classes=
|Diseases=Drug Hypersensitivity; Epidermal Necrolysis, Toxic; Stevens-Johnson Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA165291958
}}

{{PharmGKB
|RSID=rs750332
|Name_s=
|Gene_s=BAT2, BAT3
|Feature=
|Evidence=PubMed ID:16538176; Web Resource:http://www.fda.gov/cder/drug/InfoSheets/HCP/carbamazepineHCP.htm
|Annotation=This variant is associated with severe adverse reactions (Stevens Johnson syndrome and toxic epidermal necrolysis) of carbamazepine therapy.
|Drugs=carbamazepine
|Drug Classes=
|Diseases=Bipolar Disorder; Epidermal Necrolysis, Toxic; Epilepsy; Stevens-Johnson Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162263522
}}

{{PMID Auto
|PMID=21815799
|Title=Major histocompatibility complex class I chain-related gene polymorphisms: associated with susceptibility to Kawasaki disease and coronary artery aneurysms
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs750332
|overall_frequency_n=8521
|overall_frequency_d=10750
|overall_frequency=0.792651
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=89
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}