{{Rsnum
|rsid=751141
|Gene=EPHX2
|Chromosome=8
|position=27516348
|Orientation=minus
|GMAF=0.1428
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=EPHX2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 81.2 | 17.9 | 0.9
| HCB | 52.2 | 42.6 | 5.1
| JPT | 58.4 | 36.3 | 5.3
| YRI | 83.0 | 17.0 | 0.0
| ASW | 87.7 | 10.5 | 1.8
| CHB | 52.2 | 42.6 | 5.1
| CHD | 65.4 | 28.0 | 6.5
| GIH | 79.2 | 18.8 | 2.0
| LWK | 74.5 | 24.5 | 0.9
| MEX | 72.4 | 22.4 | 5.2
| MKK | 63.9 | 33.5 | 2.6
| TSI | 88.2 | 11.8 | 0.0
| HapMapRevision=28
}}{{omim
|id=132811
|rsnum=751141
|variant=0001
}}

{{ClinVar
|rsid=751141
|Reversed=1
|FwdREF=C
|FwdALT=T
|REF=G
|ALT=A
|RSPOS=27373865
|CHROM=8
|GMAF=0.1424
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x05037800000015051f110100
|GENEINFO=EPHX2:2053
|GENE_NAME=EPHX2
|GENE_ID=2053
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000008.10:g.27373865G>A
|CLNORIGIN=1
|CLNSIG=5
|Tags=RV;PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.8572; 0.1428
|CLNACC=RCV000018074.22
|CLNDBN=Familial hypercholesterolemia
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=132811.0001
|COMMON=1
|Disease=Familial hypercholesterolemia
|CLNDSDB=MedGen:OMIM:OMIM:SNOMED_CT:SNOMED_CT
|CLNDSDBID=C0020445:143890:144400:397915002:398036000
}}

{{PMID Auto
|PMID=18282109
|Title=Adaptations to climate in candidate genes for common metabolic disorders.
|OA=1
}}

{{PMID Auto
|PMID=18589104
|Title=Genetic variations in soluble epoxide hydrolase and graft function in kidney transplantation.
}}

{{PMID Auto
|PMID=21429967
|Title=In vivo activity of epoxide hydrolase according to sequence variation affects the progression of human IgA nephropathy.
}}

{{GET Evidence
|gene=EPHX2
|aa_change=Arg287Gln
|aa_change_short=R287Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs751141
|overall_frequency_n=1115
|overall_frequency_d=10758
|overall_frequency=0.103644
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|pph2_score=1.0
|nblosum100=0
|autoscore=3
|webscore=N
}}

{{PMID Auto
|PMID=23711456
|Title=Variations in the human soluble epoxide hydrolase gene and recurrence of atrial fibrillation after catheter ablation
}}

{{PMID Auto
|PMID=24368493
|Title=Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}