{{Rsnum
|rsid=7517847
|Gene=IL23R
|Chromosome=1
|position=67215986
|Orientation=plus
|GMAF=0.4031
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=IL23R
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 21.2 | 46.0 | 32.7
| HCB | 17.6 | 51.5 | 30.9
| JPT | 15.9 | 48.7 | 35.4
| YRI | 0.7 | 18.5 | 80.8
| ASW | 1.8 | 29.8 | 68.4
| CHB | 17.6 | 51.5 | 30.9
| CHD | 13.8 | 56.0 | 30.3
| GIH | 10.9 | 43.6 | 45.5
| LWK | 6.4 | 36.4 | 57.3
| MEX | 37.9 | 46.6 | 15.5
| MKK | 7.7 | 44.2 | 48.1
| TSI | 11.8 | 51.0 | 37.3
| HapMapRevision=28
}}

{{doi|10.1371/journal.pone.0023473}}  the association may be specific to [[Crohn's disease]], as opposed to all types of IBD.

{{PMID|18047539}} significant associations with [[rs1004819]], [[rs7517847]], and [[rs11209026]]. Having any CARD15 variant was associated with a significant risk for [[Crohn's disease]] (P < 0.0001).

{{PMID|17508420}} rs7517847 (P=4.9x10(-9), OR 0.65, 0.56-0.75), is statistically independent of [[rs11209026]]. 

{{PMID|18698678|OA=1
}} Replicated reduced risk for [[Crohn's disease]] with the [[rs7517847]](G) allele in a study of Italian patients, but not ulcerative colitis.

{{PMID|21253534|OA=1
}} Each incidence of the G allele was associated with a decrease in Crohn's Disease in New Zealand populations studied.

{{GWAS Summary
|SNP=rs7517847
|PubMedID=17068223
|Condition=Inflammatory bowel disease
|Gene=IL23R
|Risk Allele=C
|pValue=4.00E-013
|OR=1.61
|95CI=1.35-1.92
}}

{{PMID Auto GWAS
|PMID=17435756
|Trait=Crohn's disease
|Title=Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
|RiskAllele=
|Pval=3.0000000000000001E-12
|OR=NR
|ORtxt=NR
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 17; IBD17
|id=612261
|rsnum=7517847
}}

{{omim
|desc=INTERLEUKIN 23 RECEPTOR; IL23R
|id=607562
|rsnum=7517847
}}
{{PMID Auto
|PMID=19034457
|Title=Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility
}}
{{PMID Auto
|PMID=19895338
|Title=The Association Between Interleukin-23 Receptor Gene Polymorphisms and Systemic Lupus Erythematosus
}}

{{PharmGKB
|RSID=rs7517847
|Name_s=
|Gene_s=IL23R
|Feature=
|Evidence=PubMed ID:17068223; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A genome-wide association study identifies IL23R as an inflammatory bowel disease gene (Initial Sample Size: 547 cases, 548 controls; Replication Sample Size: 401 cases, 433 controls, 883 families, 1,119 affected offspring; Risk Allele: rs7517847-C).
|Drugs=
|Drug Classes=
|Diseases=Inflammatory Bowel Diseases
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356596
}}

{{PMID Auto
|PMID=20157760
|Title=Interleukin-23 receptor genetic polymorphisms and Crohn's disease susceptibility: a meta-analysis
}}

{{PMID Auto
|PMID=20375120
|Title=IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population
}}
{{PMID Auto
|PMID=19953089
|Title=Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
}}
{{PMID Auto
|PMID=21079743
|Title=Interaction of Crohn's Disease Susceptibility Genes in an Australian Paediatric Cohort
|OA=1
}}
{{PMID Auto
|PMID=21206965
|Title=IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes
}}

{{PMID Auto
|PMID=22089529
|Title=Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
}}

{{PMID Auto
|PMID=22735800
|Title=IL-23 Receptor Gene rs7517847 and rs1004819 SNPs in Ulcerative Colitis
}}

{{PMID Auto
|PMID=22378604
|Title=Association study of IL10 and IL23R-IL12RB2 in Iranian Behçet's disease patients.
}}

{{PMID|17678723}} Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.

{{PMID|17786191|OA=1
}} rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.

{{PMID|17901940}} Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction.

{{PMID|17924341|OA=1
}} Fine mapping versus replication in whole-genome association studies.

{{PMID|18200510}} CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population.

{{PMID|18368064}} IL23R: a susceptibility locus for celiac disease and multiple sclerosis?

{{PMID|18383521}} IL23R and IL12B polymorphisms in Spanish IBD patients: no evidence of interaction.

{{PMID|19175939|OA=1
}} IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.

{{PMID|19306001}} No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.

{{PMID|19468064|OA=1
}} Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

{{PMID|19522770}} Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples.

{{PMID|19757086}} Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.

{{PMID|20116410}} Polymorphisms of IL23R and Vogt-Koyanagi-Harada syndrome in a Chinese Han population.

{{PMID|20192940}} Association of the interleukin-23 receptor gene variant rs11209026 with Crohn's disease in German children.

{{PMID|20454450|OA=1
}} Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

{{PMID|21304977|OA=1
}} An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

{{PMID Auto
|PMID=23054009
|Title=Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7517847
|overall_frequency_n=45
|overall_frequency_d=128
|overall_frequency=0.351562
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=43
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23093364
|Title=Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis
}}

{{PMID Auto
|PMID=23840727
|Title=IL23R Gene Confers Susceptibility to Ankylosing Spondylitis Concomitant with Uveitis in a Han Chinese Population
|OA=1
}}

{{PMID Auto
|PMID=22718508
|Title=Association of interleukin 23 receptor gene polymorphisms (rs10489629, rs7517847) with rheumatoid arthritis in European population: a meta-analysis.
}}

{{PMID Auto
|PMID=23053963
|Title=Associations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
}}

{{PMID Auto
|PMID=23564312
|Title=Polymorphisms of the IL-23R gene are associated with primary immune thrombocytopenia but not with the clinical outcome of pulsed high-dose dexamethasone therapy.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}