{{Rsnum
|rsid=7524102
|Gene=ZBTB40
|Chromosome=1
|position=22371954
|Orientation=plus
|GMAF=0.2259
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 64.6 | 33.6 | 1.8
| HCB | 54.7 | 40.9 | 4.4
| JPT | 57.5 | 38.9 | 3.5
| YRI | 35.4 | 49.0 | 15.6
| ASW | 54.4 | 40.4 | 5.3
| CHB | 54.7 | 40.9 | 4.4
| CHD | 66.1 | 29.4 | 4.6
| GIH | 67.3 | 26.7 | 5.9
| LWK | 42.7 | 46.4 | 10.9
| MEX | 84.5 | 15.5 | 0.0
| MKK | 39.1 | 43.6 | 17.3
| TSI | 68.6 | 29.4 | 2.0
| HapMapRevision=28
}}{{Report GE
|PubMed=18445777
|Source=journal
|AffyProbeset=SNP_A-2092875
|AffyOrientation=same
|AlleleA=
|AlleleB=
|onGW5=
|rsid=7524102
|ancestral=G
|RiskPopulation=Caucasian
|RiskAllele=A
|CaseFreq=
|ControlFreq=
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=-
|Disease=Bone mineral density, lower
|DiseaseSymbol=BMD-L
}}

rs7524102 increases susceptibility to Bone mineral density variations, lower for carriers of the A allele {{PMID|18445777}}

rs7524102 increases susceptibility to Osteoporotic fractures 1.12 times for carriers of the A allele {{PMID|18445777}}

{{GWAS Summary
|SNP=rs7524102
|PubMedID=18445777
|Condition=Bone mineral density (spine)
|Gene=ZBTB40
|Risk Allele=A
|pValue=9.00E-009
|OR=0.11
|95CI=0.07-0.15) SD decreas
}}

{{PMID Auto GWAS
|PMID=19079262
|Trait=Bone mineral density (hip)
|Title=New sequence variants associated with bone mineral density
|RiskAllele=A
|Pval=1E-16
|OR=0.15
|ORtxt=[0.11-0.18] SD decrease
}}

{{omim
|desc=BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 3; BMND3
|id=606928
|rsnum=7524102
}}

{{omim
|desc=ZINC FINGER- AND BTB DOMAIN-CONTAINING PROTEIN 40; ZBTB40
|id=612106
|rsnum=7524102
}}
{{PMID Auto GWAS
|PMID=19801982
|Trait=Bone mineral density (spine)
|Title=Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
|RiskAllele=G
|Pval=3E-10
|OR=0.09
|ORtxt=[0.06-0.12] sd increase
|OA=1
}}

{{PharmGKB
|RSID=rs7524102
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079262; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: New sequence variants associated with bone mineral density. (Initial Sample Size: 6,865 individuals; Replication Sample Size: 8,510 individuals); (Region: 1p36.12; Reported Gene(s): Intergenic; Risk Allele: rs7524102-A); (p-value= 0.0000000000000001).This variant is associated with Bone mineral density (hip).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740137
}}
{{PMID Auto GWAS
|PMID=19915572
|Trait=Ulcerative colitis
|Title=Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
|RiskAllele=A
|Pval=3E-7
|OR=1.10
|ORtxt=[1.00-1.21]
|OA=1
}}

{{PharmGKB
|RSID=rs7524102
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18445777; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple Genetic Loci for Bone Mineral Density and Fractures (Initial Sample Size: 5,861 individuals; Replication Sample Size: 7,925 individuals; Risk Allele: rs7524102-A). This variant is associated with Bone mineral density (hip).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic; Fractures, Bone
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356560
}}

{{PharmGKB
|RSID=rs7524102
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18445777; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple Genetic Loci for Bone Mineral Density and Fractures (Initial Sample Size: 5,861 individuals; Replication Sample Size: 7,925 individuals; Risk Allele: rs7524102-A). This variant is associated with Bone mineral density (spine).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic; Fractures, Bone
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356561
}}

{{PMID Auto GWAS
|PMID=21297633
|Trait=None
|Title=Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
|RiskAllele=A
|Pval=2E-13
|OR=1.1000
|ORtxt=[1.05-1.16]
|OA=1
}}

{{PMID Auto GWAS
|PMID=21533022
|Trait=None
|Title=Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.
|RiskAllele=G
|Pval=9E-7
|OR=0.4400
|ORtxt=[NR] unit decrease
|OA=1
}}

{{PMID Auto GWAS
|PMID=21732829
|Trait=None
|Title=Wnt signaling and Dupuytren's disease.
|RiskAllele=G
|Pval=3E-9
|OR=1.2800
|ORtxt=None
}}

{{PMID Auto
|PMID=22824048
|Title=Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwanese women
}}

{{PMID|19181680|OA=1
}} Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.

{{PMID|19629617|OA=1
}} Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.

{{PMID|20534768|OA=1
}} OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.

{{PMID|20554715}} Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7524102
|overall_frequency_n=35
|overall_frequency_d=126
|overall_frequency=0.277778
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=31
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}