{{Rsnum
|rsid=7528684
|Gene=FCRL3
|Chromosome=1
|position=157701026
|Orientation=plus
|GMAF=0.4357
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FCRL3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 25.0 | 52.7 | 22.3
| HCB | 34.6 | 45.6 | 19.9
| JPT | 29.5 | 46.4 | 24.1
| YRI | 0.0 | 6.1 | 93.9
| ASW | 1.8 | 24.6 | 73.7
| CHB | 34.6 | 45.6 | 19.9
| CHD | 40.4 | 44.0 | 15.6
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 10.0 | 90.0
| MEX | 26.3 | 47.4 | 26.3
| MKK | 0.0 | 19.0 | 81.0
| TSI | 25.7 | 46.5 | 27.7
| HapMapRevision=28
}}
[[rs7528684]] has been reported to be associated with [[rheumatoid arthritis]] in a Caucasian population, following reports of a similar association in a Japanese population. {{PMID|16176992|OA=1
}}

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 0.95 (CI 0.83-1.08), and for homozygotes, 2.30 (CI 1.64-3.23). {{PMID|17179172|OA=1
}}

In a study of 645 Caucasians from Southern Spain with [[multiple sclerosis]], the [[rs7528684]](G) allele (in dbSNP orientation) was found to be somewhat protective (per allele odds ratio 0.81, CI: 0.70-0.94, p=0.007).{{PMID|18313765}}

In another report {{PMID|15838509|OA=1
}}, a summary indicates the following regarding disease and odds ratio (OR)for [[rs7528684]]:
* for [[rheumatoid arthritis]]: OR = 2.15 (CI = 1.58â€“2.93), from 830 cases and 658 controls;
* for [[SLE]]: OR = 1.49 (CI = 1.16â€“1.92), from 564 cases;
* for [[Graves' disease]] : OR = 1.79 (CI = 1.34â€“2.39), from 351 cases;
* for [[Hashimoto thyroiditis]]: OR = 1.62 (CI = 1.07â€“2.47), from 158 cases.

{{PMID|18087673}} [[rs7528684]] [[rs3792876]] and [[rs2268277]] failed to showed a statistically significant association with [[rheumatoid arthritis]]

{{PMID|18556175}} [[rs7528684]], [[rs11264799]], [[rs945635]] and [[rs3761959]] were not associated with systemic lupus erythematosus ([[SLE]]) in a study of 248 Chinese Han patients.

{{PMID Auto
|PMID=19438904
|Title=Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease
}}

{{PMID Auto
|PMID=21885492
|Title=FCRL3 -169C/C Genotype Is Associated with Anti-citrullinated Protein Antibody-positive Rheumatoid Arthritis and with Radiographic Progression
}}

{{PMID Auto GWAS
|PMID=21829393
|Trait=None
|Title=Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|RiskAllele=T
|Pval=1E-11
|OR=1.5200
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=16519819
|Title=Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
|OA=1
}}

{{PMID Auto
|PMID=16859508
|Title=Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?
|OA=1
}}

{{PMID Auto
|PMID=17389014
|Title=Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD.
}}

{{PMID Auto
|PMID=18556337
|Title=Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
|OA=1
}}

{{PMID Auto
|PMID=18759263
|Title=Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.
|OA=1
}}

{{PMID Auto
|PMID=19050767
|Title=Association between polymorphisms of FCRL3, a non-HLA gene, and Behcet's disease in a Chinese population with ophthalmic manifestations.
|OA=1
}}

{{PMID Auto
|PMID=19180233
|Title=Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.
|OA=1
}}

{{PMID Auto
|PMID=19452015
|Title=Polymorphisms of FCRL3 in a Chinese population with Vogt-Koyanagi-Harada (VKH) syndrome.
|OA=1
}}

{{PMID Auto
|PMID=19877046
|Title=The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells.
|OA=1
}}

{{PMID Auto
|PMID=22341374
|Title=Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis.
}}

{{PMID Auto
|PMID=23505439
|Title=A Refined Study of FCRL Genes from a Genome-Wide Association Study for Graves' Disease
|OA=1
}}

{{PMID Auto
|PMID=23512175
|Title=Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and systemic lupus erythematosus: a meta-analysis
}}

{{PMID Auto
|PMID=24117236
|Title=The Fc receptor-like 3 gene polymorphisms and susceptibility to autoimmune diseases: An updated meta-analysis
}}

{{PMID Auto
|PMID=23564408
|Title=The FCRL3 -169T>C polymorphism might be associated with some autoantibody presence in patients with SLE in a Polish population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}