{{Rsnum
|rsid=7530511
|Gene=IL23R
|Chromosome=1
|position=67219704
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.1309
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL23R
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 77.0 | 20.4 | 2.7
| HCB | 99.3 | 0.7 | 0.0
| JPT | 95.6 | 4.4 | 0.0
| YRI | 53.7 | 33.3 | 12.9
| ASW | 52.6 | 43.9 | 3.5
| CHB | 99.3 | 0.7 | 0.0
| CHD | 97.2 | 2.8 | 0.0
| GIH | 88.1 | 11.9 | 0.0
| LWK | 67.3 | 28.2 | 4.5
| MEX | 82.8 | 15.5 | 1.7
| MKK | 85.3 | 14.1 | 0.6
| TSI | 73.5 | 24.5 | 2.0
| HapMapRevision=28
}}
IL23R gene SNP, part of a haplotype with [[rs11209026]] associated with [[psoriasis]].{{PMID|18219280|OA=1
}}

In a study of 216 North American patients with [[Graves' disease]], the homozygous [[rs10889677]](T;T) genotype was significantly associated with Graves' disease but not specifically with Graves ophthalmopathy; the odds ratio was 9.4 (p=0.02).{{PMID|18073300|OA=1
}}

{{ neighbor
| rsid = 11465802
| distance = 210
}}

{{PMID Auto
|PMID=19705136
|Title=Genetic evidence for involvement of the IL23 pathway in Thai psoriatics
|OA=1
}}

{{PMID Auto
|PMID=17236132
|Title=A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.
|OA=1
}}

{{PMID Auto
|PMID=18369459
|Title=A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
|OA=1
}}

{{PMID Auto
|PMID=18470928
|Title=IL23R haplotypes provide a large population attributable risk for Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=19021011
|Title=Association studies of the IL-23R gene in autoimmune thyroid disease in the Japanese population.
}}

{{PMID Auto
|PMID=19035472
|Title=Investigation of association of the IL12B and IL23R genes with psoriatic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19040306
|Title=Association of interleukin 23 receptor variants with psoriatic arthritis.
}}

{{PMID Auto
|PMID=19522770
|Title=Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples.
}}

{{PMID Auto
|PMID=19757086
|Title=Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.
}}

{{PMID Auto
|PMID=19918037
|Title=Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=22378604
|Title=Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behcet's disease.
}}

{{PMID Auto
|PMID=23054009
|Title=Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis
}}

{{GET Evidence
|gene=IL23R
|aa_change=Leu310Pro
|aa_change_short=L310P
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7530511
|overall_frequency_n=9010
|overall_frequency_d=10758
|overall_frequency=0.837516
|n_genomes=54
|n_genomes_annotated=0
|n_haplomes=99
|n_articles=0
|n_articles_annotated=0
|nblosum100=7
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23093722
|Title=Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis
}}

{{PMID Auto
|PMID=24140476
|Title=Genetic variations in IL6 and IL12B decreasing the risk for psoriasis
}}

{{PMID Auto
|PMID=22706445
|Title=Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis.
}}

{{PMID Auto
|PMID=22897389
|Title=Interactions between adiposity and genetic polymorphisms on the risk of psoriasis.
}}

{{PMID Auto
|PMID=24912586
|Title=A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory Syndrome in a Kenyan population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}