{{Rsnum
|rsid=7542281
|Gene=F5
|Chromosome=1
|position=169567201
|Orientation=plus
|GMAF=0.2342
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=F5
}}[http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pgen.0030120.eor linked] to Cardiovascular Events

Several CVD risk variants were identified: In women, the combination of F5 [[rs7542281]] Ã— THBD [[rs1042580]], together with three single F5 SNPs, was associated with CVD events. Among men, PROC [[rs1041296]], when combined with either ICAM1 [[rs5030341]] or F5 [[rs2269648]], was associated with total mortality. As a single variant, PROC [[rs1401296]], together with the F5 Leiden mutation, was associated with ischemic stroke events.{{PMID|17677000|OA=1
}}

{{PMID Auto
|PMID=18974842
|Title=Gender differences in genetic risk profiles for cardiovascular disease.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}