{{Rsnum
|rsid=7561317
|Chromosome=2
|position=644953
|Orientation=plus
|GMAF=0.1667
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.5 | 22.1 | 74.3
| HCB | 0.7 | 10.9 | 88.3
| JPT | 0.0 | 20.4 | 79.6
| YRI | 6.8 | 34.9 | 58.2
| ASW | 10.5 | 42.1 | 47.4
| CHB | 0.7 | 10.9 | 88.3
| CHD | 0.0 | 19.3 | 80.7
| GIH | 1.0 | 21.8 | 77.2
| LWK | 4.5 | 30.9 | 64.5
| MEX | 5.2 | 17.2 | 77.6
| MKK | 3.2 | 44.2 | 52.6
| TSI | 3.0 | 33.7 | 63.4
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19079260
|Trait=Body mass index
|Title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
|RiskAllele=G
|Pval=4E-17
|OR=6.12
|ORtxt=[4.69-7.55] % SD
}}

{{PMID Auto
|PMID=19851340
|Title=Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
}}

{{PharmGKB
|RSID=rs7561317
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 2p25.3; Reported Gene(s): TMEM18; Risk Allele: rs7561317-G); (p-value= 0.000000000000000002).This variant is associated with Weight.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740158
}}

{{PharmGKB
|RSID=rs7561317
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 2p25.3; Reported Gene(s): TMEM18; Risk Allele: rs7561317-G); (p-value= 0.00000000000000004).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740151
}}

{{PMID Auto
|PMID=21625854
|Title=Implication of genetic variants near TMEM18, BCDIN3D/FAIM2, and MC4R with coronary artery disease and obesity in Chinese: a angiography-based study
}}

{{PMID Auto
|PMID=21912638
|Title=Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
|OA=1
}}

{{PMID|19478790|OA=1
}} The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

{{PMID|20127379|OA=1
}} From monogenic to polygenic obesity: recent advances.

{{PMID|20380707|OA=1
}} The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children.

{{PMID|20712903|OA=1
}} Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7561317
|overall_frequency_n=108
|overall_frequency_d=128
|overall_frequency=0.84375
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=92
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23860325
|Title=Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes
}}

{{PMID Auto
|PMID=24348519
|Title=EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}