{{Rsnum
|rsid=7566605
|Chromosome=2
|position=118078449
|Orientation=plus
|GMAF=0.2957
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 7.1 | 38.9 | 54.0
| HCB | 13.2 | 50.0 | 36.8
| JPT | 8.0 | 50.4 | 41.6
| YRI | 6.1 | 35.4 | 58.5
| ASW | 0.0 | 33.3 | 66.7
| CHB | 13.2 | 50.0 | 36.8
| CHD | 14.8 | 53.7 | 31.5
| GIH | 6.9 | 37.6 | 55.4
| LWK | 5.5 | 27.5 | 67.0
| MEX | 12.3 | 50.9 | 36.8
| MKK | 8.4 | 38.1 | 53.5
| TSI | 14.9 | 37.6 | 47.5
| HapMapRevision=28
}}[[rs7566605]] was initially reported as being associated in at least 4 independent populations as being associated with [[obesity]] however replications are inconsistent, and a recent (2009) large meta-analysis comprising 34 studies (and over 70,000 subjects) has concluded that there is no evidence for overall association of the rs7566605 polymorphism with obesity.{{PMID|19851442|OA=1
}} See also: {{PMID|16614226}} [http://www.microarraybulletin.com/community/uploaded_images/WorkflowPDFs/C_H_WFChart.pdf Poster]

At least one population has since been reported in which this association was not seen. {{PMID|17218508}} Furthermore, a study of 18,000 Danish subjects also failed to find any direct role for this SNP in the development of [[obesity]], except that among physically inactive subjects, (C)-allele carriers tended to have a higher body mass index (by O.5 kg/m2) than (G)-allele carriers.{{PMID|18682847|OA=1
}}

On the other hand, a report has also been published indicating that obese children who are [[rs7566605(C;C)]] homozygotes find it harder to lose weight in clinical intervention programs than (C;G) heterozygotes or (G;G) homozygotes, which supports the association of SNP [[rs7566605]] with [[obesity]]. {{PMID|18003761}} 

{{PMID|18570692}} associated with the prevalence of [[hypercholesterolemia]], but '''not''' with obesity, in Japanese American women. In Japanese American women, [[rs7566605]](C;C) individuals had a 0.43-fold decreased risk (CI: 0.24 - 0.80) for hypercholesterolemia compared with the (G;G) homozygotes after adjustment for age and other factors. No significant differences in BMI, waist girth and percentage body fat according to the genotype in each of the four groups, which was divided by population and sex. The [[rs7566605]](C;C) genotype is suggested to be a protective genetic factor against the progression of hypercholesterolemia on a high-fat diet, especially in Japanese female subjects.

{{PMID|18839134|OA=1
}} [[rs9939609]] and [[rs7566605]] linked to obesity

{{PMID|19105843|OA=1
}} underlies variation in subcutaneous adiposity in young adult women and suppresses the positive effects of resistance training on men.

{{PMID|19197259}} does not influence BMI and is not associated directly with CAD/MI or indirectly through cardiovascular risk factors

{{PMID|19197262}} [[rs7566605]] is not associated with obesity-related traits and lipids in the ~2,00 person European Youth Heart Study.

{{PMID|19197259}} rs7566605 near the INSIG2 gene does not influence BMI and is not associated directly with CAD/MI or indirectly through cardiovascular risk factors in a study of ~7,000 German adults.

{{PMID Auto
|PMID=19263810
|Title=Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents
}}
{{PMID Auto
|PMID=19360016
|Title=INSIG2 SNPs Associated With Obesity and Glucose Homeostasis Traits in Hispanics: The IRAS Family Study
|OA=1
}}

{{PMID Auto
|PMID=19399648
|Title=Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants
}}
{{PMID Auto
|PMID=19523229
|Title=The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
|OA=1
}}

{{omim
|desc=BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 13; BMIQ13
|id=612459
|rsnum=7566605
}}
{{PMID Auto
|PMID=19772594
|Title=Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations
|OA=1
}}

{{PharmGKB
|RSID=rs7566605
|Name_s=
|Gene_s=INSIG2
|Feature=
|Evidence=PubMed ID:16614226; PubMed ID:17218508; PubMed ID:17218509; PubMed ID:17218510
|Annotation=rs7566605 has been studied for association with obesity, with conflicting findings.
|Drugs=
|Drug Classes=
|Diseases=Obesity
|Curation Level=Curated
|PharmGKB Accession ID=PA161889389
}}
{{PMID Auto
|PMID=20028541
|Title=A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans
|OA=1
}}
{{PMID Auto
|PMID=20045156
|Title=Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age
|OA=1
}}

{{PMID Auto
|PMID=20373477
|Title=Association study of polymorphisms in Insulin Induced Gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients
}}
{{PMID Auto
|PMID=20858904
|Title=Fine Mapping of the INSIG2 Gene Identifies a Variant Associated with Low-Density Lipoprotein Cholesterol and Total ApoB Levels
}}
{{PMID Auto
|PMID=20920244
|Title=Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent
|OA=1
}}
{{PMID Auto
|PMID=20955599
|Title=The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
|OA=1
}}
{{PMID Auto
|PMID=20504252
|Title=Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample
}}

{{PMID Auto
|PMID=17024366
|Title=Lack of association between rs7566605 and obesity in a Chinese population.
}}

{{PMID Auto
|PMID=17137505
|Title=INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.
|OA=1
}}

{{PMID Auto
|PMID=17389899
|Title=Is rs7566605, a SNP near INSIG2, associated with body mass in a randomized clinical trial of antipsychotics in schizophrenia?
}}

{{PMID Auto
|PMID=17465681
|Title=The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.
|OA=1
}}

{{PMID Auto
|PMID=17471297
|Title=INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.
}}

{{PMID Auto
|PMID=17489846
|Title=The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.
}}

{{PMID Auto
|PMID=17903300
|Title=Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project.
|OA=1
}}

{{PMID Auto
|PMID=18070740
|Title=No association between rs7566605 variant and being overweight in Japanese.
}}

{{PMID Auto
|PMID=18096054
|Title=Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample.
|OA=1
}}

{{PMID Auto
|PMID=18162505
|Title=Identification and replication of a novel obesity locus on chromosome 1q24 in isolated populations of Cilento.
}}

{{PMID Auto
|PMID=18223638
|Title=No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population.
}}

{{PMID Auto
|PMID=18239574
|Title=INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.
}}

{{PMID Auto
|PMID=18270535
|Title=Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation.
}}

{{PMID Auto
|PMID=18304332
|Title=No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins.
|OA=1
}}

{{PMID Auto
|PMID=18325910
|Title=Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.
|OA=1
}}

{{PMID Auto
|PMID=18387595
|Title=On the replication of genetic associations: timing can be everything!
|OA=1
}}

{{PMID Auto
|PMID=18426866
|Title=Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
|OA=1
}}

{{PMID Auto
|PMID=18514965
|Title=A common polymorphism is associated with body mass index in Uyghur population.
}}

{{PMID Auto
|PMID=18615239
|Title=INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.
|OA=1
}}

{{PMID Auto
|PMID=19079261
|Title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
|OA=1
}}

{{PMID Auto
|PMID=19107338
|Title=Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan.
}}

{{PMID Auto
|PMID=19224890
|Title=Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention.
}}

{{PMID Auto
|PMID=19245693
|Title=Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.
|OA=1
}}

{{PMID Auto
|PMID=19478790
|Title=The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
|OA=1
}}

{{PMID Auto
|PMID=19593725
|Title=Association of maternally inherited GNAS alleles with African-American male birth weight.
|OA=1
}}

{{PMID Auto
|PMID=19965593
|Title=INSIG1 influences obesity-related hypertriglyceridemia in humans.
|OA=1
}}

{{PMID Auto
|PMID=20092643
|Title=Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).
|OA=1
}}

{{PMID Auto
|PMID=20127379
|Title=From monogenic to polygenic obesity: recent advances.
|OA=1
}}

{{PMID Auto
|PMID=20354568
|Title=INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months.
|OA=1
}}

{{PMID Auto
|PMID=20645959
|Title=An INSIG2 polymorphism affects glucose homeostasis in Sardinian obese children and adolescents.
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=21233811
|Title=Multilocus analyses of seven candidate genes suggest interacting pathways for obesity-related traits in Brazilian populations.
}}

{{PMID Auto
|PMID=21283731
|Title=FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7566605
|overall_frequency_n=88
|overall_frequency_d=128
|overall_frequency=0.6875
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=79
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

[[Obesity: Preliminary Research]]

{{PMID Auto
|PMID=23941145
|Title=Association between intramuscular fat in the arm following arm training and INSIG2
}}

{{PMID Auto
|PMID=24167462
|Title=FTO and INSIG2 Genotyping Combined with Metabolic and Anthropometric Phenotyping of Morbidly Obese Patients
|OA=1
}}

{{PMID Auto
|PMID=22038464
|Title=Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content.
}}

{{PMID Auto
|PMID=22968099
|Title=INSIG2 variants, dietary patterns and metabolic risk in Samoa.
|OA=1
}}

{{PMID Auto
|PMID=23318717
|Title=Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}