{{Rsnum
|rsid=7569963
|Gene=FAM119A
|Chromosome=2
|position=207608460
|Orientation=plus
|GMAF=0.1809
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 12.3 | 43.1 | 44.6
| HCB | 0.0 | 20.0 | 80.0
| JPT | 0.0 | 22.7 | 77.3
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 20.0 | 80.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs7569963]] is directly adjacent to [[CREB1]].

{{PMID|17548750}} Associated with significantly (p = 0.005) increased chance of [[suicide]] in a study of 1447 citalopram users (male only subgroup, 539 in total). Two haplotypes (see below) also showed significant association with suicidality in the male subgroup.
*[[rs2709376]](C),[[rs2253206]](A),[[rs7569963]](A),[[rs7594560]](T),[[rs4675690]](C) - common haplotype, reduced chance of suicide in males, p = 0.004
*[[rs2709376]](C),[[rs2253206]](A),[[rs7569963]](G),[[rs7594560]](T),[[rs4675690]](T) - increased chance of suicide in males, p = 0.009

{{PharmGKB
|RSID=rs7569963
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17548750
|Annotation=In a nested case-control study derived from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study this SNP in the CREB1 gene was associated with treatment-emergent suicidality among men with depression.
|Drugs=citalopram
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA162263536
}}

{{PMID Auto
|PMID=20643483
|Title=A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7569963
|overall_frequency_n=30
|overall_frequency_d=128
|overall_frequency=0.234375
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=25
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}