{{Rsnum
|rsid=7578597
|Gene=THADA
|Chromosome=2
|position=43505684
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.1198
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=THADA
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 24.8 | 75.2
| HCB | 0.0 | 0.7 | 99.3
| JPT | 0.0 | 1.8 | 98.2
| YRI | 8.2 | 49.0 | 42.9
| ASW | 5.3 | 43.9 | 50.9
| CHB | 0.0 | 0.7 | 99.3
| CHD | 0.0 | 0.9 | 99.1
| GIH | 3.0 | 28.7 | 68.3
| LWK | 10.9 | 47.3 | 41.8
| MEX | 0.0 | 5.2 | 94.8
| MKK | 5.1 | 30.8 | 64.1
| TSI | 1.0 | 9.8 | 89.2
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs7578597
|PubMedID=18372903
|Condition=Type 2 diabetes
|Gene=THADA
|Risk Allele=T
|pValue=1.00E-009
|OR=1.15
|95CI=1.10-1.20
|OA=1
}}

{{PMID Auto
|PMID=19789630
|Title=Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study
|OA=1
}}
{{PMID Auto
|PMID=19862325
|Title=PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population
|OA=1
}}

{{PharmGKB
|RSID=rs7578597
|Name_s=
|Gene_s=THADA
|Feature=
|Evidence=PubMed ID:18372903; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes (Initial Sample Size: 4,549 cases, 5,579 controls; Replication Sample Size: 24,194 cases, 55,598 controls; Risk Allele: rs7578597-T).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356766
}}

{{PMID Auto
|PMID=22052079
|Title=Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs
|OA=1
}}

{{PMID Auto
|PMID=18567820
|Title=Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.
|OA=1
}}

{{PMID Auto
|PMID=18591388
|Title=Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
|OA=1
}}

{{PMID Auto
|PMID=18694974
|Title=Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
|OA=1
}}

{{PMID Auto
|PMID=18714373
|Title=Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18782870
|Title=Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19020323
|Title=Genotype score in addition to common risk factors for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19056611
|Title=Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|OA=1
}}

{{PMID Auto
|PMID=19096518
|Title=Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19207020
|Title=Meta-analysis in genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=19323962
|Title=Genome-wide association studies in type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19324937
|Title=Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
|OA=1
}}

{{PMID Auto
|PMID=19341491
|Title=Genome-based prediction of common diseases: methodological considerations for future research.
|OA=1
}}

{{PMID Auto
|PMID=19401414
|Title=Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=19455305
|Title=No association of multiple type 2 diabetes loci with type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19460916
|Title=Genetic architecture of type 2 diabetes: recent progress and clinical implications.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19502414
|Title=Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
|OA=1
}}

{{PMID Auto
|PMID=19526209
|Title=Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
|OA=1
}}

{{PMID Auto
|PMID=19602701
|Title=Underlying genetic models of inheritance in established type 2 diabetes associations.
|OA=1
}}

{{PMID Auto
|PMID=19670153
|Title=Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits.
}}

{{PMID Auto
|PMID=19741467
|Title=Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
}}

{{PMID Auto
|PMID=19956539
|Title=How many genetic variants remain to be discovered?
|OA=1
}}

{{PMID Auto
|PMID=20017978
|Title=Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20043853
|Title=Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=20075150
|Title=Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20144327
|Title=A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21602532
|Title=Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies.
}}

{{PMID Auto
|PMID=22237986
|Title=Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.
|OA=1
}}

{{PMID Auto
|PMID=22377712
|Title=Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
}}

{{GET Evidence
|gene=THADA
|aa_change=Thr1187Ala
|aa_change_short=T1187A
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7578597
|overall_frequency_n=1501
|overall_frequency_d=9604
|overall_frequency=0.156289
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|pph2_score=0.384
|nblosum100=1
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23036851
|Title=Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}