{{Rsnum
|rsid=7582694
|Gene=STAT4
|Chromosome=2
|position=191105394
|Orientation=plus
|GMAF=0.2668
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=STAT4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 6.3 | 31.5 | 62.2
| HCB | 13.3 | 44.4 | 42.2
| JPT | 14.3 | 38.4 | 47.3
| YRI | 3.4 | 25.9 | 70.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 13.3 | 44.4 | 42.2
| CHD | 11.1 | 52.8 | 36.1
| GIH | 9.1 | 50.5 | 40.4
| LWK | 12.3 | 25.5 | 62.3
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 6.9 | 29.7 | 63.4
| HapMapRevision=28
}}
Several tightly linked SNPs in the [[STAT4]] gene have been linked to risk for risk haplotype for systemic lupus erythematosus ([[SLE]]). The strongest association is found for either of two perfectly linked SNP alleles, [[rs10181656]](G) and [[rs7582694]](C), both yielding an odds ratio of 1.71 in this study of ~700 Swedish SLE patients.{{PMID|18579578|OA=1
}}

The risk for SLE was also calculated to increase as a function of the total number of risk alleles for this SNP plus 2 others in the [[IRF5]] gene, [[rs10488631]] and a CGGGG indel, rs77571059. Compared to individuals with 0 or 1 risk alleles, the risk for SLE increased 1.82-fold for each additional risk allele from this group. The odds ratio for SLE is 2.08 (CI: 1.53-2.83) for carriers of 2 risk alleles, and goes up to 13.0 (CI: 3.78-44.3) for carriers of 5 or 6 risk alleles (compared to those with 0 or 1).
{{PMID|18579578|OA=1
}}

{{ neighbor
| rsid = 10181656
| distance = 241
}}

{{PMID Auto
|PMID=20535138
|Title=STAT4 is a confirmed genetic risk factor for SjÃ¶gren's syndrome and could be involved in type 1 interferon pathway signaling
}}

{{PMID|19092842}} Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjogren's syndrome.

{{PMID|19333953|OA=1
}} High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.

{{PMID|19717398}} Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort.

{{PMID|20454450|OA=1
}} Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

{{PMID|21167895}} Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in a Northern Han Chinese population.

{{PMID|21258797}} A single-nucleotide polymorphism of the STAT4 gene is associated with systemic lupus erythematosus (SLE) in female Chinese population.

{{PMID Auto
|PMID=24386384
|Title=Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
|OA=1
}}

{{PMID Auto
|PMID=22729903
|Title=Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish population.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}