{{Rsnum
|rsid=760805
|Gene=RUNX3
|Chromosome=1
|position=24925432
|Orientation=plus
|GMAF=0.4229
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=RUNX3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 18.8 | 43.8 | 37.5
| HCB | 21.4 | 50.0 | 28.6
| JPT | 23.3 | 55.8 | 20.9
| YRI | 98.3 | 1.7 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 21.4 | 50.0 | 28.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs760805]], a SNP in the [[RUNX3]] gene, has been reported to be the most significantly associated with risk for [[bladder cancer]] of several SNPs in this gene, based on a study of 368 Chinese patients. The adjusted odds ratio for the [[rs760805]](A;A) genotype is 1.97 (CI: 1.44-2.69).{{PMID|18684727}}

Further investigation of this region in this same study indicated that 4 other SNPs in the [[RUNX3]] gene, as well as smoking, are associated with increased risk for [[bladder cancer]]. In particular, 2 haplotypes, both containing the [[rs760805]](A) allele, were associated with 2-3x increased risk. An individual carrying the risk forms of all 5 RUNX3 SNPs and also smoking had on average an odds ratio for [[bladder cancer]] that was 6.37 fold higher than average (CI: 4.57-8.87, p = 7.03 x 10(-28)).{{PMID|18684727}}

{{PMID Auto
|PMID=19552756
|Title=Genetic variants in the Runt-related transcription factor 3 gene contribute to gastric cancer risk in a Chinese population
}}
{{PMID Auto
|PMID=19728008
|Title=Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}