{{Rsnum
|rsid=762421
|Chromosome=21
|position=44195678
|Orientation=plus
|GMAF=0.3843
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=C21orf33
|Gene_s=C21orf33
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 36.3 | 45.1 | 18.6
| HCB | 20.4 | 52.6 | 27.0
| JPT | 21.2 | 50.4 | 28.3
| YRI | 85.7 | 14.3 | 0.0
| ASW | 58.9 | 37.5 | 3.6
| CHB | 20.4 | 52.6 | 27.0
| CHD | 30.3 | 48.6 | 21.1
| GIH | 38.6 | 49.5 | 11.9
| LWK | 85.5 | 13.6 | 0.9
| MEX | 10.3 | 41.4 | 48.3
| MKK | 84.6 | 14.7 | 0.6
| TSI | 36.3 | 48.0 | 15.7
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18587394
|Trait=Crohn's disease
|Title=Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease
|RiskAllele=G
|Pval=1.0000000000000001E-9
|OR=1.13
|ORtxt=[NR]
|OA=1
}}

DeCode reports that [[rs762421]] is associated with susceptibility to [[Crohn's disease]]. {{PMID|18587394|OA=1
}}

{{PMID|19068216|OA=1
}} Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

{{PMID|19557189|OA=1
}} Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

{{PMID|21304977|OA=1
}} An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs762421
|overall_frequency_n=95
|overall_frequency_d=128
|overall_frequency=0.742188
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=80
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24480412
|Title=PTPN2 rs1893217 single-nucleotide polymorphism is associated with risk of Behçet's disease in a Chinese Han population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}