{{Rsnum
|rsid=7639618
|Gene=DVWA
|Chromosome=3
|position=15174922
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.2635
|Gene_s=COL6A4P1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 68.1 | 28.3 | 3.5
| HCB | 30.7 | 48.9 | 20.4
| JPT | 32.7 | 53.1 | 14.2
| YRI | 63.9 | 34.0 | 2.0
| ASW | 57.9 | 40.4 | 1.8
| CHB | 30.7 | 48.9 | 20.4
| CHD | 30.3 | 46.8 | 22.9
| GIH | 41.6 | 50.5 | 7.9
| LWK | 57.3 | 35.5 | 7.3
| MEX | 55.2 | 39.7 | 5.2
| MKK | 72.4 | 22.4 | 5.1
| TSI | 78.4 | 21.6 | 0.0
| HapMapRevision=28
}}
[[rs7639618]] is one of several SNPs in the [[DVWA]] gene found to be associated with [[osteoarthritis]] based on a study of several Japanese patient populations. The allelic odds ratio is 1.45 (CI: 1.27-1.65, p = 2.2 x 10e-8) for the minor allele, which is the (T) allele (in dbSNP orientation). {{PMID|18622395}}

{{PMID|19054821}} Our results suggest that the effect that DVWA amino acid changes have on tubulin binding is unlikely to influence risk of OA in Caucasians.

{{PMID|19181678}} [[rs7639618]] with knee [[osteoarthritis]] with an odds ratio (OR) of 1.29, 95% confidence interval (CI) of 1.15 -1.45 and P of 2.70x10(-5), but not for Europeans

{{omim
|desc=OSTEOARTHRITIS SUSCEPTIBILITY 6; OS6
|id=612401
|rsnum=7639618
}}

{{PMID Auto
|PMID=19486942
|Title=The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5' part of the split COL6A4 gene
}}

{{PMID Auto
|PMID=20238217
|Title=Lack of evidence for association between DVWA gene polymorphisms and developmental dysplasia of the hip in Chinese Han population
}}

{{PMID Auto
|PMID=22083612
|Title=Association study of the candidate gene for knee osteoarthritis in Koreans.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}