{{Rsnum
|rsid=7643645
|Gene=NR1I2
|Chromosome=3
|position=119806650
|Orientation=plus
|GMAF=0.3209
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NR1I2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 49.2 | 43.1 | 7.7
| HCB | 22.2 | 48.9 | 28.9
| JPT | 25.0 | 52.3 | 22.7
| YRI | 95.2 | 4.8 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 22.2 | 48.9 | 28.9
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=19940802
|Title=The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease
}}

{{PharmGKB
|RSID=rs7643645
|Name_s=
|Gene_s=NR1I2
|Feature=Intron
|Evidence=PubMed ID:19940802
|Annotation=Risk or phenotype-associated allele: G. Phenotype: The multimarker composed of rs2461823/A-rs7643645/G was significantly associated with severity of nonalcoholic fatty liver disease (NAFLD) (P<6.9x10, beta: 0.45). In univariate analysis rs7643645/G was significantly associated with fatty liver disease (P<0.04), with an odds ratio of 1.457 (95% confidence interval: 1.018-2.086). Study size: 290. Study population/ethnicity: 188 NAFLD patients with different stages of disease severity and 102 healthy individuals. Type of association: GN.
|Drugs=
|Drug Classes=
|Diseases=Fatty Liver
|Curation Level=Curated
|PharmGKB Accession ID=PA165110551
}}

{{PMID Auto
|PMID=19958310
|Title=The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy
}}

{{PMID|17048007|OA=1
}} Association of warfarin dose with genes involved in its action and metabolism.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7643645
|overall_frequency_n=38
|overall_frequency_d=128
|overall_frequency=0.296875
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23609392
|Title=Pharmacogenetic study on risperidone long-acting injection: influence of cytochrome P450 2D6 and pregnane X receptor on risperidone exposure and drug-induced side-effects.
}}

{{PMID Auto
|PMID=24924803
|Title=The PXR rs7643645 Polymorphism Is Associated with the Risk of Higher Prostate-Specific Antigen Levels in Prostate Cancer Patients
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}