{{Rsnum
|rsid=7646054
|Gene=ARHGEF3
|Chromosome=3
|position=56775600
|Orientation=plus
|GMAF=0.3122
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ARHGEF3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 26.8 | 38.4 | 34.8
| HCB | 4.5 | 28.8 | 66.7
| JPT | 2.7 | 18.6 | 78.8
| YRI | 4.1 | 35.9 | 60.0
| ASW | 10.5 | 50.9 | 38.6
| CHB | 4.5 | 28.8 | 66.7
| CHD | 4.7 | 38.3 | 57.0
| GIH | 21.0 | 42.0 | 37.0
| LWK | 8.2 | 39.1 | 52.7
| MEX | 29.3 | 36.2 | 34.5
| MKK | 15.4 | 43.6 | 41.0
| TSI | 11.8 | 40.2 | 48.0
| HapMapRevision=28
}}
[[rs7646054]] is a SNP in the [[ARHGEF3]] gene.

A study of 769 Australian female siblings found that the [[rs7646054]](G) allele was significantly associated with lower bone mineral density (BMD) and thus [[osteoporosis]] in an age-related manner. Significant associations with hip and spine BMD were confirmed (p = 0.003-0.038), as well as an association with fracture rate (p = 0.02).

{{PharmGKB
|RSID=rs7646054
|Name_s=
|Gene_s=ARHGEF3
|Feature=
|Evidence=PubMed ID:18499081
|Annotation=In family-based association tests, five SNPs(of which rs7646054 showed the strongest association) demonstrated significant association with decreased age-adjusted bone mineral density. The initial findings were in women from Australia and the UK, and the association was replicated in a cohort of postmenopausal women from the UK.
|Drugs=
|Drug Classes=
|Diseases=Fractures, Bone; Osteoporosis, Postmenopausal
|Curation Level=Curated
|PharmGKB Accession ID=PA161748314
}}

{{PMID Auto
|PMID=19727905
|Title=Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7646054
|overall_frequency_n=89
|overall_frequency_d=128
|overall_frequency=0.695312
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=74
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}