{{Rsnum
|rsid=7647305
|Chromosome=3
|position=186116501
|Orientation=plus
|GMAF=0.2241
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 67.0 | 25.9 | 7.1
| HCB | 85.9 | 13.3 | 0.7
| JPT | 88.0 | 12.0 | 0.0
| YRI | 31.2 | 56.2 | 12.5
| ASW | 37.5 | 41.1 | 21.4
| CHB | 85.9 | 13.3 | 0.7
| CHD | 86.1 | 13.9 | 0.0
| GIH | 49.5 | 38.4 | 12.1
| LWK | 27.1 | 51.4 | 21.5
| MEX | 65.5 | 31.0 | 3.4
| MKK | 44.5 | 46.5 | 9.0
| TSI | 67.0 | 31.0 | 2.0
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19079260
|Trait=Body mass index
|Title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
|RiskAllele=C
|Pval=7E-11
|OR=4.42
|ORtxt=[3.09-5.75] % SD
}}

{{PharmGKB
|RSID=rs7647305
|Name_s=
|Gene_s=ETV5
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 3q27.2; Reported Gene(s): SFRS10, ETV5, DGKG; Risk Allele: rs7647305-C); (p-value= 0.00000000007).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740150
}}

{{PMID Auto
|PMID=20061430
|Title=Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population
}}

{{PharmGKB
|RSID=rs7647305
|Name_s=
|Gene_s=ETV5
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 3q27.2; Reported Gene(s): SFRS10, ETV5, DGKG; Risk Allele: rs7647305-C); (p-value= 0.000000004).This variant is associated with Weight.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740160
}}

{{PMID Auto
|PMID=21796141
|Title=Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
}}

{{PMID Auto
|PMID=21912638
|Title=Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
|OA=1
}}

{{PMID Auto
|PMID=19478790
|Title=The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
|OA=1
}}

{{PMID Auto
|PMID=19526209
|Title=Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
|OA=1
}}

{{PMID Auto
|PMID=19553259
|Title=Common body mass index-associated variants confer risk of extreme obesity.
|OA=1
}}

{{PMID Auto
|PMID=20127379
|Title=From monogenic to polygenic obesity: recent advances.
|OA=1
}}

{{PMID Auto
|PMID=20520848
|Title=Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=20824172
|Title=Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7647305
|overall_frequency_n=97
|overall_frequency_d=128
|overall_frequency=0.757812
|n_genomes=54
|n_genomes_annotated=0
|n_haplomes=82
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Obesity: Preliminary Research]]

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}