{{Rsnum
|rsid=7657958
|Gene=UGT2B10
|Chromosome=4
|position=68817077
|Orientation=plus
|GMAF=0.05556
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=UGT2B10
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 1.5 | 18.5 | 80.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 4.8 | 95.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs7657958]] (Asp67Tyr, 199G>T) is a SNP within the [[UGT2B10]] (UDP-glucuronosyltransferase 2B10) gene.

{{PMID|18300939}} Tyr allele defines haplotype C, significantly associated with lower 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, a nitrosamine found in tobacco) N-glucuronidation, an 1.8-fold and 12-fold reduction in NNAL-N-glucuronidation was found for one and two haplotype C alleles, respectively

{{PMID|19786624|OA=1
}} may effect [[nicotine]] metabolism

{{PharmGKB
|RSID=rs7657958
|Name_s=tagging SNP for UGT2B10:199G>T (Asp67Tyr)
|Gene_s=UGT2B10
|Feature=
|Evidence=PubMed ID:17909004; PubMed ID:18300939
|Annotation=The UGT2B1067Tyr variant corresponding to the UGT2B10 haplotype C is a functional single nucleotide polymorphism that may be responsible for inter individual variation in NNAL-N-glucuronidation activity and may increase susceptibility to smoking-related cancers.
|Drugs=nicotine
|Drug Classes=
|Diseases=Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA164728240
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7657958
|overall_frequency_n=8
|overall_frequency_d=126
|overall_frequency=0.0634921
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}