{{Rsnum
|rsid=7679
|Gene=PCIF1
|Chromosome=20
|position=45947863
|Orientation=plus
|GMAF=0.1006
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PCIF1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 2.7 | 28.3 | 69.0
| HCB | 0.0 | 5.1 | 94.9
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.7 | 99.3
| ASW | 0.0 | 3.5 | 96.5
| CHB | 0.0 | 5.1 | 94.9
| CHD | 0.0 | 4.6 | 95.4
| GIH | 9.9 | 32.7 | 57.4
| LWK | 0.0 | 12.7 | 87.3
| MEX | 3.4 | 25.9 | 70.7
| MKK | 0.0 | 26.0 | 74.0
| TSI | 2.0 | 27.5 | 70.6
| HapMapRevision=28
}}per the [http://blog.23andme.com/2008/12/08/new-papers-from-nature-genetics-yield-a-bounty-of-cholesterol-snps/ 23andMe blog], the minor allele of this SNP (C) was associated with decreased HDL [[cholesterol]] and increased [[triglycerides]]
 
{| border="1"
|-
!SNP
!Rarer allele
!LDL
!HDL
!TG
|-
| [[rs6544713]] || T || + || ||
|-
| [[rs2650000]] || A || + || ||
|-
| [[rs471364]] || C || || - ||
|-
| [[rs1800961]] || T || || - ||
|-
| [[rs7679]] || C || || - || +
|-
| [[rs2967605]] || T || || - ||
|-
| [[rs2409722]] || T || || || -
|-
| [[rs10903129]] || A || - || - || -
|-
| [[rs6756629]] || A || - || + || -
|-
| [[rs12670798]] || C || + || + || +
|-
| [[rs7395662]] || A || - || + || +
|-
| [[rs174570]] || T || - || - || +
|-
| [[rs2271293]] || A || - || + || -
|-
| [[rs2624265]] || C || || || +
|-
| [[rs2167079]] || T || || + ||
|-
| [[rs9891572]] || T || || + ||
|-
| [[rs4844614]] || T || + || ||
|-
| [[rs5031002]] || G || + || ||
|-
|}

{{PMID Auto GWAS
|PMID=19060906
|Trait=HDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=C
|Pval=4E-9
|OR=0.07
|ORtxt=[0.03-0.11] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs7679
|Name_s=
|Gene_s=ZNF335, PCIF1
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 20q13.12; Reported Gene(s): PLTP; Risk Allele: rs7679-C); (p-value= 0.000000004).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740236
}}

{{PharmGKB
|RSID=rs7679
|Name_s=
|Gene_s=ZNF335, PCIF1
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 20q13.12; Reported Gene(s): PLTP; Risk Allele: rs7679-C); (p-value= 0.00000000007).This variant is associated with Triglycerides.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740267
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20160193
|Title=Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
|OA=1
}}

{{PMID Auto
|PMID=20385826
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|OA=1
}}

{{PMID Auto
|PMID=21347282
|Title=Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7679
|overall_frequency_n=11
|overall_frequency_d=126
|overall_frequency=0.0873016
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=8
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}