{{Rsnum
|rsid=769449
|Gene=APOE
|Chromosome=19
|position=44906745
|Orientation=plus
|GMAF=0.08219
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=APOE
}}{{PMID Auto GWAS
|PMID=18439548
|Trait=C-reactive protein
|Title=Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study
|RiskAllele=
|Pval=8.9999999999999994E-21
|OR=0.26
|ORtxt=[NR] mg/dl decrease
|OA=1
}}

{{PharmGKB
|RSID=rs769449
|Name_s=
|Gene_s=APOE, APOC1
|Feature=
|Evidence=PubMed ID:18439548
|Annotation=In a GWAS of apparently healthy women, seven loci were found to be significantly associated with C-Reactive protein levels. Two SNPs in APOE were significantly associated with CRP, and of these, this SNP showed the most significant association.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161614224
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19802338
|Title=Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.
|OA=1
}}

{{PMID Auto
|PMID=20031577
|Title=Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=21647738
|Title=Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
|OA=1
}}

{{PMID Auto
|PMID=22234866
|Title=Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs769449
|overall_frequency_n=267
|overall_frequency_d=3234
|overall_frequency=0.0825603
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23562540
  |Trait=Alzheimer's disease biomarkers
  |Title=GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
  |RiskAllele=A
  |Pval=2E-16
  |OR=.08
  |ORtxt=[NR] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=24468470
|Title=Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}