{{Rsnum
|rsid=769455
|Gene=APOE
|Chromosome=19
|position=44908783
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.009642
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=APOE
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 0.0 | 0.0
| HCB | 0.0 | 0.0 | 0.0
| JPT | 0.0 | 0.0 | 0.0
| YRI | 93.8 | 6.2 | 0.0
| ASW | 96.4 | 3.6 | 0.0
| CHB | 0.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 95.5 | 4.5 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
{{omim
|desc=HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE2
|id=107741
|rsnum=769455
|variant=0004
}}

The ancestral allele is C.

{{ neighbor
| rsid = 28931578
| distance = 32
}}
{{ neighbor
| rsid = 7412
| distance = 39
}}

{{ClinVar
|rsid=769455
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=45412040
|CHROM=19
|GMAF=0.0096
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x050268000000040517110100
|GENEINFO=APOE:348
|GENE_NAME=APOE
|GENE_ID=348
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.45412040C>T
|CLNORIGIN=1
|CLNSIG=5
|Tags=PM;PMC;S3D;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9904; 0.009642
|CLNACC=RCV000019432.27; RCV000019443.26
|CLNDBN=Familial type 3 hyperlipoproteinemia
|CLNDSDB=MedGen:SNOMED_CT
|CLNDSDBID=C0020479:398796005
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=107741.0004; 107741.0013
|COMMON=1
|Disease=Familial type 3 hyperlipoproteinemia
}}

{{PMID|17658295}} Association of ApoE genetic variants with obstructive sleep apnea in children.

{{PMID|17672902|OA=1
}} Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes.

{{GET Evidence
|gene=APOE
|aa_change=Arg163Cys
|aa_change_short=R163C
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs769455
|overall_frequency_n=49
|overall_frequency_d=9548
|overall_frequency=0.00513196
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=1.0
|genetests_testable=Y
|nblosum100=8
|autoscore=4
|n_web_uneval=2
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}