{{Rsnum
|rsid=774359
|Gene=C9orf72
|Chromosome=9
|position=27561051
|Orientation=plus
|GMAF=0.1997
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=C9orf72
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 9.7 | 33.6 | 56.6
| HCB | 0.8 | 15.0 | 84.2
| JPT | 0.0 | 14.3 | 85.7
| YRI | 0.7 | 35.2 | 64.1
| ASW | 5.3 | 28.1 | 66.7
| CHB | 0.8 | 15.0 | 84.2
| CHD | 0.9 | 17.0 | 82.1
| GIH | 2.0 | 29.0 | 69.0
| LWK | 7.3 | 40.9 | 51.8
| MEX | 1.7 | 8.6 | 89.7
| MKK | 5.9 | 42.5 | 51.6
| TSI | 10.9 | 40.6 | 48.5
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19734901
|Trait=Amyotrophic lateral sclerosis
|Title=Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
|RiskAllele=
|Pval=0.000003
|OR=1.19
|ORtxt=[NR]
}}

{{PharmGKB
|RSID=rs774359
|Name_s=
|Gene_s=C9orf72
|Feature=
|Evidence=PubMed ID:18615156
|Annotation=This variant is significantly associated with the efficacy of anti-TNF treatment in rheumatoid arthritis (Adjusted P-value: 0.0000006; OR: 5.4 (1.9, 17.3)). The study is a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning of anti-TNF therapy.
|Drugs=adalimumab; etanercept; infliximab
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162928828
}}

{{PMID Auto
|PMID=20423481
|Title=Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs774359
|overall_frequency_n=30
|overall_frequency_d=128
|overall_frequency=0.234375
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}