{{Rsnum
|rsid=7759938
|Chromosome=6
|position=104931079
|Orientation=plus
|GMAF=0.3893
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 7.1 | 58.4 | 34.5
| HCB | 8.0 | 38.0 | 54.0
| JPT | 1.8 | 49.6 | 48.7
| YRI | 37.4 | 46.3 | 16.3
| ASW | 24.6 | 59.6 | 15.8
| CHB | 8.0 | 38.0 | 54.0
| CHD | 7.3 | 46.8 | 45.9
| GIH | 11.9 | 47.5 | 40.6
| LWK | 45.5 | 44.5 | 10.0
| MEX | 5.2 | 37.9 | 56.9
| MKK | 28.8 | 50.0 | 21.2
| TSI | 10.8 | 42.2 | 47.1
| HapMapRevision=28
}}[[rs7759938]] is a SNP from chromosomal region 6q21 showing a strong association with age at [[menarche]] in a study of 17,500 Icelandic women.

Per copy carried of the [[rs7759938]](T) allele, age at menarche is delayed about 1 month.

{{PMID Auto GWAS
|PMID=19448620
|Trait=Menarche
|Title=Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
|RiskAllele=C
|Pval=7E-9
|OR=0.09
|ORtxt=[0.05-0.13] years older
|OA=1
}}

{{PMID Auto GWAS
|PMID=21102462
|Trait=None
|Title=Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
|RiskAllele=C
|Pval=5E-60
|OR=6.4000
|ORtxt=[5.62-7.18] week increase
|OA=1
}}
{{omim
|id=606255
|rsnum=7759938
}}

{{omim
|id=612882
|rsnum=7759938
}}

{{PMID Auto
|PMID=22822098
|Title=Functional Study of Risk Loci of Stem Cell-associated Gene Lin-28B and Associations with Disease Survival Outcomes in Epithelial Ovarian Cancer
}}

{{PMID|20398887|OA=1
}} Distinct variants at LIN28B influence growth in height from birth to adulthood.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7759938
|overall_frequency_n=81
|overall_frequency_d=128
|overall_frequency=0.632812
|n_genomes=46
|n_genomes_annotated=0
|n_haplomes=68
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23152804
|Title=Association of LIN28B with Adult Adiposity-Related Traits in Females
|OA=1
}}

{{PMID Auto GWAS
  |PMID=20881960
  |Trait=Height
  |Title=Hundreds of variants clustered in genomic loci and biological pathways affect human height.
  |RiskAllele=T
  |Pval=8E-31
  |OR=.05
  |ORtxt=[NR] unit decrease
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=23449627
  |Trait=Pubertal anthropometrics
  |Title=Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
  |RiskAllele=C
  |Pval=4E-9
  |OR=.11
  |ORtxt=[0.079-0.141] unit increase
  }}

{{PMID Auto
|PMID=23740805
|Title=Replication of LIN28B SNP association with age of menarche in young Filipino women
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}