{{Rsnum
|rsid=7771980
|Gene=RUNX2
|Chromosome=6
|position=45421552
|Orientation=plus
|GMAF=0.07208
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=RUNX2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 19.0 | 81.0
| HCB | 0.0 | 24.4 | 75.6
| JPT | 0.0 | 29.5 | 70.5
| YRI | 0.0 | 1.6 | 98.4
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 24.4 | 75.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs7771980]], also known as -1025T>C, is a SNP in the [[RUNX2]] gene, which encodes an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification.

This SNP has been reported to be significantly associated with bone mineral density (BMD; and thus [[osteoporosis]] in several studies, but with different correlations.

In a study of 821 Spanish postmenopausal women, [[rs7771980]](C;T) women had higher mean adjusted femoral neck bone BMD values than those bearing the (T;T) genotype.{{PMID|17878995}}

In a study of 729 postmenopausal Korean women, the significant association found was that (C;C) women showed a significant association with reduced lumbar spine BMD and proximal femur sites compared with (C;T) or (T;T) subjects.{{PMID|19424741}}

{{PMID Auto
|PMID=18357615
|Title=Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}