{{Rsnum
|rsid=7775
|Gene=FRZB
|Chromosome=2
|position=182834857
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.1134
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=FRZB
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 90.8 | 9.2 | 0.0
| HCB | 97.8 | 2.2 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 41.3 | 52.4 | 6.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 97.8 | 2.2 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs7775]] (R324G) [[osteoarthritis]] at multiple joints (p = 0.07), particularly in the hip in women {{PMID|17237116|OA=1
}} 

associated with [[osteoarthritis]] of the hip in females

This is an arg324-to-gly (R324G) substitution

{{PMID|19479880}} Meta-analysis of 14 studies did not support a significant association between [[rs7775]] and osteoarthritis.

{{omim
|desc=OSTEOARTHRITIS OF HIP, FEMALE-SPECIFIC, SUSCEPTIBILITY TO
|id=605083
|rsnum=7775
|variant=0001
}}

{{PMID Auto
|PMID=22095095
|Title=Variant alleles of the WNT antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis
}}

{{ClinVar
|rsid=7775
|Reversed=1
|FwdREF=C
|FwdALT=G
|REF=G
|ALT=C
|RSPOS=183699584
|CHROM=2
|GMAF=0.1131
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05016800000015051f110101
|GENEINFO=FRZB:2487
|GENE_NAME=FRZB
|GENE_ID=2487
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000002.11:g.183699584G>C
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=605083.0001
|CLNSIG=255
|CLNCUI=C0029408
|CLNDBN=Osteoarthritis susceptibility 1
|Disease=Osteoarthritis susceptibility 1
|CLNACC=RCV000005530.1
|Tags=RV;PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.8866; 0.1134
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C0029408:165720
|COMMON=1
}}

{{PMID|15210948|OA=1
}} Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

{{PMID|18787887|OA=1
}} Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.

{{PMID|20043861|OA=1
}} No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.

{{PMID|22544526|OA=1
}} Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.

{{GET Evidence
|gene=FRZB
|aa_change=Arg324Gly
|aa_change_short=R324G
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7775
|overall_frequency_n=1672
|overall_frequency_d=10758
|overall_frequency=0.155419
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|in_omim=Y
|pph2_score=0.993
|nblosum100=6
|autoscore=3
|webscore=N
}}

{{PMID Auto
|PMID=23516639
|Title=Association of single nucleotide polymorphisms in wnt signaling pathway genes with breast cancer in saudi patients
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}