{{Rsnum
|rsid=7775228
|Gene=HLA-DQB1
|Chromosome=6
|position=32690302
|Orientation=plus
|GMAF=0.1974
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 2.7 | 19.5 | 77.9
| HCB | 6.6 | 38.7 | 54.7
| JPT | 8.0 | 50.4 | 41.6
| YRI | 4.8 | 32.7 | 62.6
| ASW | 3.5 | 24.6 | 71.9
| CHB | 6.6 | 38.7 | 54.7
| CHD | 2.8 | 36.7 | 60.6
| GIH | 5.0 | 41.6 | 53.5
| LWK | 0.9 | 22.7 | 76.4
| MEX | 5.2 | 25.9 | 69.0
| MKK | 1.9 | 23.7 | 74.4
| TSI | 2.9 | 29.4 | 67.6
| HapMapRevision=28
}}

[[rs7775228]] is one of three HLA region SNPs used to tag the DQ2.2 haplotype in [[gs221]]. {{PMID|18509540|OA=1
}}

[[rs7775228]](T) was found to be associated with increased risk for [[osteoarthritis]] among Japanese, but not Europeans, with an odds ratio of 1.34 (CI: 1.21-1.49, combined p = 2.43×10e?8). This SNP is also in linkage disequilibrium with [[rs10947262]], which was found to be associated in multiple populations with [[osteoarthritis]].{{PMID|20305777|OA=1
}}

[[23andMe]] reports that the C allele at rs7775228 is associated with hay fever (allergic rhinitis and allergy to grass pollen. {{PMID|22036096}}

{{PMID Auto
|PMID=19950296
|Title=Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1
}}

{{PMID Auto GWAS
|PMID=21804548
|Trait=None
|Title=Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
|RiskAllele=A
|Pval=5E-15
|OR=1.1700
|ORtxt=[1.12-1.21]
}}

{{PMID|19458352|OA=1
}} Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}