{{Rsnum
|rsid=7794745
|Gene=CNTNAP2
|Chromosome=7
|position=146792514
|Orientation=plus
|GMAF=0.4766
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=CNTNAP2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 47.8 | 41.6 | 10.6
| HCB | 37.2 | 42.3 | 20.4
| JPT | 41.6 | 43.4 | 15.0
| YRI | 1.4 | 21.1 | 77.6
| ASW | 7.0 | 49.1 | 43.9
| CHB | 37.2 | 42.3 | 20.4
| CHD | 38.5 | 49.5 | 11.9
| GIH | 34.7 | 57.4 | 7.9
| LWK | 0.9 | 31.8 | 67.3
| MEX | 48.2 | 42.9 | 8.9
| MKK | 1.3 | 34.0 | 64.7
| TSI | 38.2 | 51.0 | 10.8
| HapMapRevision=28
}}
A common SNP in the [[CNTNAP2]] gene, [[rs7794745]], is associated with increased risk for [[autism]] based on a study of 148 affected children from families with two more autistic children.{{PMID|18179894|OA=1
}}

[http://www.medpagetoday.com/Pediatrics/Autism/tb/7917 Related article]

{{omim
|id=604569
|desc=CONTACTIN-ASSOCIATED PROTEIN-LIKE 2; CNTNAP2
|rsnum=7794745
}}

{{PharmGKB
|RSID=rs7794745
|Name_s=
|Gene_s=CNTNAP2
|Feature=
|Evidence=PubMed ID:18179894
|Annotation=This common variant in CNTNAP2 is significantly associated with autism susceptibility in two independent family-based samples.
|Drugs=
|Drug Classes=
|Diseases=Autistic Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162168112
}}

{{PMID Auto
|PMID=20176116
|Title=Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2
|OA=1
}}

{{PMID Auto
|PMID=20414140
|Title=Association analysis of CNTNAP2 polymorphisms with autism in the Chinese Han population
}}

{{omim
|id=604569
|rsnum=7794745
|variant=0003
}}

{{PMID|19456320|OA=1
}} A genome-wide association study of autism reveals a common novel risk locus at 5p14.1.

{{PMID|20446882}} Do candidate genes discriminate patients with an autism spectrum disorder from those with attention deficit/hyperactivity disorder and is there an effect of lifetime substance use disorders?

{{PMID|21193173|OA=1
}} A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits.

{{PMID|21987501}} Genetic variation in CNTNAP2 alters brain function during linguistic processing in healthy individuals.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7794745
|overall_frequency_n=64
|overall_frequency_d=128
|overall_frequency=0.5
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=59
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23115634
|Title=CNTNAP2 and Language Processing in Healthy Individuals as Measured with ERPs
|OA=1
}}

{{PMID Auto
|PMID=23277129
|Title=Analysis of two language-related genes in autism: a case-control association study of FOXP2 and CNTNAP2.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}