{{Rsnum
|rsid=7799039
|Chromosome=7
|position=128238730
|Orientation=plus
|GMAF=0.4334
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 24.8 | 47.8 | 27.4
| HCB | 64.2 | 31.4 | 4.4
| JPT | 57.5 | 39.8 | 2.7
| YRI | 0.0 | 2.0 | 98.0
| ASW | 1.8 | 17.5 | 80.7
| CHB | 64.2 | 31.4 | 4.4
| CHD | 49.1 | 41.7 | 9.3
| GIH | 27.7 | 43.6 | 28.7
| LWK | 0.0 | 10.1 | 89.9
| MEX | 13.8 | 46.6 | 39.7
| MKK | 0.0 | 25.7 | 74.3
| TSI | 23.5 | 52.0 | 24.5
| HapMapRevision=28
}}{{PMID Auto
|PMID=19142102
|Title=Polymorphisms of the LEP- and LEPR gene and obesity in patients using antipsychotic medication.
}}

{{PMID Auto
|PMID=19921265
|Title=The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
}}

{{PharmGKB
|RSID=rs7799039
|Name_s=LEP: -2548G/A
|Gene_s=LEP
|Feature=
|Evidence=PubMed ID:19873684
|Annotation=Risk or phenotype-associated allele(s): G/G. Phenotype:the GG-genotype carriers were 2.5 times less likely to be overweight/obese (i.e. having a BMI above the 85th percentile). Study population/ethnicity: Children and adolescents, aged 7-17 years, treated with risperidone for 6 months or more.
|Drugs=risperidone
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165110519
}}

{{PMID Auto
|PMID=20140086
|Title=Genetic Variation at Selected SNPs in the Leptin Gene and Association of Alleles with Markers of Kidney Disease in a Xhosa Population of South Africa
|OA=1
}}
{{PMID Auto
|PMID=20183928
|Title=The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
}}

{{PMID Auto
|PMID=20517895
|Title=Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training
}}
{{PMID Auto
|PMID=20562674
|Title=Association between LEP and LEPR gene polymorphisms and dyslipidemia in patients using atypical antipsychotic medication
}}
{{PMID Auto
|PMID=20504252
|Title=Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample
}}

{{PMID Auto
|PMID=21510767
|Title=Polymorphisms of the LEP-, LEPR and HTR2C gene: obesity and BMI change in patients using antipsychotic medication in a naturalistic setting
}}

{{PMID Auto
|PMID=22669627
|Title=Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers
|OA=1
}}

{{PMID Auto
|PMID=15197684
|Title=Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=17879022
|Title=Are common leptin promoter polymorphisms associated with restenosis after coronary stenting?
}}

{{PMID Auto
|PMID=18059035
|Title=Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions.
|OA=1
}}

{{PMID Auto
|PMID=18923972
|Title=The -2548G/A LEP polymorphism is associated with blood pressure in Tunisian obese patients.
}}

{{PMID Auto
|PMID=18992263
|Title=Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.
|OA=1
}}

{{PMID Auto
|PMID=19035456
|Title=Adipokine genes and prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19204185
|Title=Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=19337797
|Title=Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population.
}}

{{PMID Auto
|PMID=19593725
|Title=Association of maternally inherited GNAS alleles with African-American male birth weight.
|OA=1
}}

{{PMID Auto
|PMID=19604093
|Title=Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
|OA=1
}}

{{PMID Auto
|PMID=19623271
|Title=A Bayesian hierarchical model for analysis of SNP diversity in multilocus, multipopulation samples.
|OA=1
}}

{{PMID Auto
|PMID=19942621
|Title=An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.
|OA=1
}}

{{PMID Auto
|PMID=20201642
|Title=Associations of polymorphisms in adiponectin and leptin genes with men's longevity.
}}

{{PMID Auto
|PMID=22020349
|Title=Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7799039
|overall_frequency_n=51
|overall_frequency_d=128
|overall_frequency=0.398438
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23284729
|Title=Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits
|OA=1
}}

{{PMID Auto
|PMID=24146750
|Title=Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=22426215
|Title=Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain.
}}

{{PMID Auto
|PMID=23433430
|Title=The impact of obesity-related SNP on appetite and energy intake.
}}

{{PMID Auto
|PMID=23754448
|Title=LEP gene variant is associated with prostate cancer but not with colorectal cancer.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}