{{Rsnum
|rsid=780094
|Gene=GCKR
|Chromosome=2
|position=27518370
|Orientation=plus
|GMAF=0.3857
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=GCKR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 15.0 | 48.7 | 36.3
| HCB | 32.1 | 48.9 | 19.0
| JPT | 33.6 | 46.0 | 20.4
| YRI | 2.0 | 19.7 | 78.2
| ASW | 0.0 | 29.8 | 70.2
| CHB | 32.1 | 48.9 | 19.0
| CHD | 32.1 | 45.0 | 22.9
| GIH | 3.0 | 33.7 | 63.4
| LWK | 0.9 | 16.5 | 82.6
| MEX | 12.3 | 38.6 | 49.1
| MKK | 0.0 | 0.0 | 0.0
| TSI | 22.5 | 55.9 | 21.6
| HapMapRevision=28
}}{{PMID|19241058}} rs780094, a SNP in the [[GCKR]] gene encoding the glucokinase regulatory protein, contributes to the risk of [[type-2 diabetes]] and dyslipidaemia in mulitple populations. The effect on type 2 diabetes is probably mediated through impaired beta cell function rather than through obesity. The [[rs780094]](A) risk allele is associated with the following traits {{PMID|18008060}}:

* higher levels of fasting serum triacylglycerol
* impaired fasting and OGTT-related insulin release
* dyslipidemia
* somewhat reduced risk of [[type-2 diabetes]]

There may also be an additive effect between this SNP and a SNP known as 'GCK -30A', [[rs1799884]], at least on fasting serum insulin levels. {{PMID|18008060}}

{{PMID|18596051}} [[rs780094]] influences severe [[hypertriglyceridemia]]. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched normolipidemic controls.

{{PMID|18678614|OA=1
}} [[rs780094]] may be acting as a proxy for a nearby tightly linked (r(2)=0.93) SNP, [[rs1260326]], which encodes a common missense GCKR variant. Both are linked to opposite effects on fasting plasma triglyceride and glucose concentrations, and, associated with C-reactive protein levels.

{{GWAS Summary
|SNP=rs780094
|PubMedID=18193043
|Condition=Triglycerides
|Gene=GCKR
|Risk Allele=T
|pValue=6.00E-032
|OR=8.59
|95CI=NR) mg/dl highe
}}

{{PMID Auto GWAS
|PMID=19060911
|Trait=Triglycerides
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=G
|Pval=3E-20
|OR=0.10
|ORtxt=[NR] SD decrease
|OA=1
}}
{{PMID Auto GWAS
|PMID=18439548
|Trait=C-reactive protein
|Title=Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study
|RiskAllele=A
|Pval=7.0000000000000001E-15
|OR=0.14
|ORtxt=[NR] mg/dl increase
|OA=1
}}
{{PMID Auto GWAS
|PMID=18193044
|Trait=Triglycerides
|Title=Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
|RiskAllele=T
|Pval=2.9999999999999998E-14
|OR=0.13
|ORtxt=[0.09-0.17]% SD higher
|OA=1
}}
{{PMID Auto GWAS
|PMID=18179892
|Trait=LDL cholesterol
|Title=Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
|RiskAllele=T
|Pval=4.9999999999999998E-7
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PMID Auto GWAS
|PMID=19503597
|Trait=Uric acid concentrations
|Title=Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations
|RiskAllele=T
|Pval=1E-9
|OR=0.05
|ORtxt=[0.035-0.068] mg/dl increase
|OA=1
}}
{{PMID Auto
|PMID=19890391
|Title=Common polymorphisms influencing serum uric Acid levels contribute to susceptibility to gout, but not to coronary artery disease
|OA=1
}}

{{PharmGKB
|RSID=rs780094
|Name_s=
|Gene_s=GCKR
|Feature=
|Evidence=PubMed ID:20081858
|Annotation=Phenotype 1 : In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with fasting glucose level. Study size: 118,032. Significance metric(s): p = 5.6 x 10(-38). Phenotype 2 : In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with fasting insulin level. Study size: 96,126. Significance metric(s): p = 3.6 x 10(-20). Phenotype 3 : In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with HOMA-IR (homeostasis model assessment of insulin resistance). Study size: 94,636. Significance metric(s): p = 3.0 x 10(-24). Study population/ethnicity: Non-diabetic Individuals of European descent. Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA165281937
}}

{{PMID Auto
|PMID=19656773
|Title=A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia
|OA=1
}}

{{PMID Auto GWAS
|PMID=20081858
|Trait=Fasting glucose-related traits
|Title=New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
|RiskAllele=C
|Pval=6E-38
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=20574426
|Title=The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population
}}
{{PMID Auto
|PMID=20661421
|Title=Association of rs780094 in GCKR with Metabolic Traits and Incident Diabetes and Cardiovascular Disease: The ARIC Study
|OA=1
}}
{{PMID Auto
|PMID=20693352
|Title=Interactions of dietary whole grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies
|OA=1
}}
{{PMID Auto
|PMID=20839289
|Title=Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose
|OA=1
}}
{{PMID Auto
|PMID=20352598
|Title=Glucokinase-activating GCKR polymorphisms increase plasma levels of triglycerides and free fatty acids, but do not elevate cardiovascular risk in the Ludwigshafen Risk and Cardiovascular Health Study
}}

{{omim
|desc=GLUCOKINASE REGULATORY PROTEIN; GCKR
|id=600842
|rsnum=780094
}}

{{PharmGKB
|RSID=rs780094
|Name_s=
|Gene_s=GCKR
|Feature=
|Evidence=PubMed ID:17463246
|Annotation=In a GWAS of Finnish and Swedish Type 2 Diabetes patients and controls, rs780094 showed replicated association with triglyceride levels.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162168093
}}

{{PharmGKB
|RSID=rs780094
|Name_s=
|Gene_s=GCKR
|Feature=
|Evidence=PubMed ID:18439548
|Annotation=In a GWAS of apparantly healthy women, seven loci were found to be significantly associated with C-Reactive protein levels. Three SNPs were significant in GCKR, and this was the lead SNP.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161614207
}}

{{PharmGKB
|RSID=rs780094
|Name_s=
|Gene_s=GCKR
|Feature=
|Evidence=PubMed ID:18193043; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Newly identified loci that influence lipid concentrations and risk of coronary artery disease (Initial Sample Size: 8,684 individuals; Replication Sample Size: 5,312-9,707 individuals; Risk Allele: rs780094-T). This variant is associated with triglyceride levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356714
}}

{{PharmGKB
|RSID=rs780094
|Name_s=
|Gene_s=GCKR
|Feature=
|Evidence=PubMed ID:18439548; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study (Initial Sample Size: 6,345 women; Replication Sample Size: NR; Risk Allele: rs780094-A). This variant is associated with C-reactive protein levels.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Metabolic Syndrome X; Myocardial Infarction; Stroke
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356794
}}

{{PharmGKB
|RSID=rs780094
|Name_s=
|Gene_s=GCKR
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 17,815 individuals; Replication Sample Size: NR); (Region: 2p23.3; Reported Gene(s): GCKR; Risk Allele: rs780094-G); (p-value= 3E-20).This variant is associated with Triglycerides.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740229
}}
{{PMID Auto
|PMID=21036910
|Title=Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
|OA=1
}}

{{omim
|id=613463
|rsnum=780094
}}

{{PMID Auto
|PMID=21411509
|Title=Variants of GCKR Affect Both {beta}-Cell and Kidney Function in Patients With Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study 2
|OA=1
}}

{{PMID|21421807|OA=1
}} In a study conducted on 6,580 Nondiabetic Finnish Men, the glucose-increasing allele of rs780094 in GCKR was significantly associated with low concentrations of VLDL particles (independently of their size) and small LDL and was nominally associated with low concentrations of intermediate-density lipoprotein, all LDL subclasses, and high concentrations of very large and large HDL particles.

{{PMID Auto
|PMID=21525158
|Title=Triglyceride Response to an Intensive Lifestyle Intervention Is Enhanced in Carriers of the GCKR Pro446Leu Polymorphism
|OA=1
}}

{{PMID Auto
|PMID=21149302
|Title=Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
|OA=1
}}

{{PMID Auto
|PMID=21887289
|Title=Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin
|OA=1
}}

{{PMID Auto GWAS
|PMID=21829377
|Trait=None
|Title=Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium.
|RiskAllele=T
|Pval=9E-9
|OR=0.0200
|ORtxt=[NR] % increase
|OA=1
}}

{{PMID Auto
|PMID=22015968
|Title=Genes Related to Diabetes May Be Associated With Pancreatic Cancer in a Population-Based Case-Control Study in Minnesota
|OA=1
}}

{{PMID Auto GWAS
|PMID=21886157
|Trait=None
|Title=Human metabolic individuality in biomedical and pharmaceutical research.
|RiskAllele=T
|Pval=6E-53
|OR=0.1010
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22553379
|Title=Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men
|OA=1
}}

{{PMID Auto GWAS
|PMID=22399527
|Trait=None
|Title=Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|RiskAllele=A
|Pval=6E-20
|OR=0.1300
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=17903299
|Title=A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=18439552
|Title=Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
|OA=1
}}

{{PMID Auto
|PMID=18521185
|Title=Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
|OA=1
}}

{{PMID Auto
|PMID=18556336
|Title=The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.
|OA=1
}}

{{PMID Auto
|PMID=18587394
|Title=Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19056598
|Title=Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.
|OA=1
}}

{{PMID Auto
|PMID=19060907
|Title=Variants in MTNR1B influence fasting glucose levels.
|OA=1
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{PMID Auto
|PMID=19068216
|Title=Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
|OA=1
}}

{{PMID Auto
|PMID=19073768
|Title=Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.
|OA=1
}}

{{PMID Auto
|PMID=19096518
|Title=Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19111066
|Title=Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits.
|OA=1
}}

{{PMID Auto
|PMID=19148283
|Title=Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=19161620
|Title=An open access database of genome-wide association results.
|OA=1
}}

{{PMID Auto
|PMID=19185284
|Title=Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19197348
|Title=Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|OA=1
}}

{{PMID Auto
|PMID=19336475
|Title=Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
|OA=1
}}

{{PMID Auto
|PMID=19435741
|Title=Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19533084
|Title=Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.
|OA=1
}}

{{PMID Auto
|PMID=19679263
|Title=Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.
|OA=1
}}

{{PMID Auto
|PMID=19802338
|Title=Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.
|OA=1
}}

{{PMID Auto
|PMID=19822575
|Title=Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing.
|OA=1
}}

{{PMID Auto
|PMID=19861489
|Title=Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms.
}}

{{PMID Auto
|PMID=19937311
|Title=Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
}}

{{PMID Auto
|PMID=20017967
|Title=Genome-wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome-wide linkage results.
|OA=1
}}

{{PMID Auto
|PMID=20031577
|Title=Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20043853
|Title=Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=20081857
|Title=Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|OA=1
}}

{{PMID Auto
|PMID=20152958
|Title=A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels.
|OA=1
}}

{{PMID Auto
|PMID=20161779
|Title=Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.
|OA=1
}}

{{PMID Auto
|PMID=20162742
|Title=Predictive value of 8 genetic loci for serum uric acid concentration.
|OA=1
}}

{{PMID Auto
|PMID=20162743
|Title=Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series.
|OA=1
}}

{{PMID Auto
|PMID=20502693
|Title=Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=20625834
|Title=Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people.
}}

{{PMID Auto
|PMID=20628598
|Title=Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
|OA=1
}}

{{PMID Auto
|PMID=20668700
|Title=Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.
|OA=1
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=21318467
|Title=Glucokinase regulatory protein (GCKR) gene rs4425043 polymorphism is associated with overweight and obesity in Chinese women.
}}

{{PMID Auto
|PMID=21423719
|Title=Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
|OA=1
}}

{{PMID Auto
|PMID=21643755
|Title=Common functional variants of APOA5 and GCKR accumulate gradually in association with triglyceride increase in metabolic syndrome patients.
}}

{{PMID Auto
|PMID=22354904
|Title=Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study.
}}

{{PMID Auto
|PMID=22395765
|Title=Association between gout and polymorphisms in GCKR in male Han Chinese.
}}

{{PMID Auto GWAS
|PMID=22581228
|Trait=None
|Title=A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|RiskAllele=
|Pval=3E-10
|OR=None
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs780094
|overall_frequency_n=90
|overall_frequency_d=128
|overall_frequency=0.703125
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=3
|n_articles_annotated=2
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23150898
|Title=Evaluation of seven common lipid associated loci in a large Indian sib pair study
|OA=1
}}

{{PMID Auto
|PMID=23587283
|Title=Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four U.S. populations: The Population Architecture using Genomics and Epidemiology (PAGE) study
}}

{{PMID Auto
|PMID=23840762
|Title=Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk
|OA=1
}}

{{PMID Auto
|PMID=23990951
|Title=Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a han chinese population
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23726366
  |Trait=Triglycerides
  |Title=Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations.
  |RiskAllele=C
  |Pval=7E-9
  |OR=.07
  |ORtxt=[NR] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=24477042
|Title=Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals
}}

{{PMID Auto
|PMID=22517333
|Title=Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.
}}

{{PMID Auto
|PMID=23307301
|Title=Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.
}}

{{PMID Auto
|PMID=23456907
|Title=Maternal genotype and gestational diabetes.
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{PMID Auto
|PMID=23712608
|Title=Genetic variability related to serum uric acid concentration and risk of Parkinson's disease.
}}

{{PMID Auto
|PMID=23800943
|Title=Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene.
}}

{{PMID Auto
|PMID=24804806
|Title=The association between Mediterranean Diet Score and glucokinase regulatory protein gene variation on the markers of cardiometabolic risk: an analysis in the European Prospective Investigation into Cancer (EPIC)-Norfolk study
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}